Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):ONLS
АТХ:B.01.A.E.04 Melagatran
Pharmacodynamics:Competitively and reversibly inhibits free and bound α-thrombin, which converts in the coagulation cascade the conversion of fibrinogen into fibrin. This prevents thrombus formation.
Pharmacokinetics:After subcutaneous administration, the maximum concentration in the blood plasma is reached after 30 minutes. Not exposed to metabolism.
T ½ is 2-3 hours. Elimination by the kidneys in unchanged form.
Indications:It is used for the prophylaxis of thromboembolic complications for patients who underwent a planned operation of knee or hip joint endoprotezisation.
IX.I26-I28.I26 Pulmonary embolism
IX.I70-I79.I74 Embolism and thrombosis of the arteries
IX.I80-I89.I82 Embolism and thrombosis of other veins
Contraindications: Chronic renal and hepatic insufficiency, bleeding, age under 18, pregnancy and lactation, individual intolerance.
Carefully: Patients older than 75 years with a body weight below 50 kg.
Pregnancy and lactation: Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration: Subcutaneously, 3 mg not earlier than 4 hours and no later than 8 hours after the operation. Then 2 times / day for 1-2 days.
The highest daily dose: 6 mg.
The highest single dose: 3 mg.
Side effects: Central and peripheral nervous system: headache, dizziness.
The cardiovascular system: tachycardia or bradycardia, hypertension or hypotension.
Hemopoietic system: anemia, bleeding.
Digestive system: indigestion, diarrhea, constipation.
Dermatological reactions: a rash.
urinary system: retention of urine.
Allergic reactions.
Overdose: Cases of overdose are not described.
Treatment is symptomatic.
Interaction: With simultaneous use with erythromycin, clarithromycin, azithromycin, antagonists K, heparin, acetylsalicylic acid, cyclosporine increases the risk of bleeding.
Special instructions: The drug is not used for intramuscular injection.