Symptoms overdose similar to the symptoms arising from atropine poisoning: mydriasis, dry skin, hyperemia of the face, dry mouth and upper respiratory tract, fever, tachycardia, cardiac arrhythmias, weakness of intestinal peristalsis, urinary retention, delirium, disorientation, anxiousness, hallucinations, confusion , ataxia, aggression and convulsions.With severe poisoning, stupor, coma, stopping of breathing and heart, lethal outcome are possible.
Giving help: gastric lavage, symptomatic therapy. It is recommended to prescribe physostigmine, as a specific antagonist at a dose of 1 mg intramuscularly or by slow intravenous infusion. This dose can be repeated every 20 minutes, but the total amount should not exceed 4 mg per day. Since physostigmine is rapidly metabolized, it is sometimes necessary to additionally inject physostigmine every 1-2 hours. For children and elderly patients, the administration of half the standard dose is recommended. The patient should be under the supervision of the doctor at least 8-12 hours after the last appearance of the symptoms.