From the digestive system: nausea, vomiting, heartburn, diarrhea, especially when using high doses of the drug (however, diarrhea is not always a consequence of the side effect of the drug, or it may be a manifestation of the underlying disease); decreased appetite, abdominal pain, dry mouth, stomatitis; increased activity of "hepatic" transaminases in plasma, hepatitis, pancreatitis.
From the cardiovascular system: palpitation, tachycardia, hypertension or hypotension, chest pain, dyspnoea. There are separate reports on the development of pericarditis, conduction disorders of the heart.
From the central nervous system: headache, tinnitus, dizziness, polyneuropathy, tremor, convulsions, insomnia, depression, hallucinations.
From the genitourinary system: proteinuria, hematuria, crystalluria, oliguria, anuria, nephrotic syndrome, oligospermia. Individual cases of impotence are described.
On the part of the hematopoiesis system: eosinophilia, anemia (hemolytic, megablastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia.
Allergic reactions: skin rash, itching, erythema, dermatosis, bronchospasm.
Other: weakness, parotitis, photosensitization, lupus-like syndrome, alopecia, a decrease in the production of tear fluid.