Metazide (Methazide)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substanceMetazideMetazide
Similar drugsTo uncover
  • Metazide
    pills inwards 
    FARMASINTEZ, JSC (Irkutsk)     Russia
  • Metazide
    pills inwards 
    UZOLE-SIBERIAN CHEMICAL PLANT, OJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    Active substance: 500 mg of metaside.

    Excipients: potato starch - 7.5 mg, low-substituted hydroxypropyl cellulose - 21.7 mg, povidone (collidon-25) - 15.8 mg, calcium stearate -5.0 mg.

    Description:Round flat cylindrical tablets of white color with a facet and a risk.
    Pharmacotherapeutic group:Anti-tuberculosis drug
    ATX: & nbsp

    J.04.A.K   Other antituberculous drugs

    Pharmacodynamics:

    Metaside is a synthetic antituberculous agent.

    Metazide has a high bacteriostatic activity in relation to Mycobacterium Tuberculosis.

    Suppress the growth and development of mycobacteria tuberculosis. He is particularly active in relation to actively dividing Mycobacterium Tuberculosis (including those located intracellularly). It breaks the synthesis of phospholipids of membranes and forms chelate complexes with divalent metal cathinones, which changes the normal vital activity of the microorganism and the synthesis of nucleic acids; stops reproduction of mycobacterium tuberculosis. With monotherapy, resistance develops faster.

    Pharmacokinetics:

    The metaside is well absorbed from the gastrointestinal tract.Admission during meals reduces absorption. Easily penetrates the blood-brain barrier. After ingestion, the maximum concentration in the blood is reached after 1 hour, and the tuberculostatic is maintained for 24 hours. In the liver, acetylated, excreted with bile, acetylated metabolite is not active.

    The drug is excreted mainly by the kidneys in the form of metabolites and in an unchanged form.

    Indications:

    All forms and localization of tuberculosis in adults and children (in combination with other anti-TB drugs).

    Contraindications:
    • Hypersensitivity to metaside;
    • pregnancy, lactation;
    • angina pectoris; decompensated heart defects;
    • organic diseases of the central nervous system and peripheral nerves, visual impairment, epilepsy and attacks of tonic-clonic seizures in the anamnesis;
    • kidney disease of a non-tubercular nature, as well as with impaired excretory function;
    • liver failure.
    Dosing and Administration:

    Inside, adults of 500 mg. 2 times a day.

    The highest daily intake for adults is 2 g.

    Children at a rate of 20-30 mg / kg in 2-3 receptions.

    The highest daily intake for children is 1 g.

    Side effects:

    Headache, dizziness, nausea, vomiting, dry mouth, pain in the heart and epigastria, skin allergic reactions, euphoria, sleep deterioration, in rare cases - development of psychosis, memory disorder, peripheral nerve and optic neuritis, violation coordination of movement, muscle twitching, drug hepatitis, in men - gynecomastia, in women - menorrhagia. In patients with epilepsy, convulsive seizures may increase. The defeat of the liver and kidneys, atrophy of the optic nerve, agranulocytosis, leukopenia, thrombocytopenia, methemoglobinemia.

    Interaction:

    Strengthens (mutually) the effect of other anti-tuberculosis drugs.

    Form release / dosage:Tablets 500 mg.
    Packaging:

    Primary packaging of medicinal product.

    For 10 tablets, in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    For 100 tablets in a can of polymer with a lid pulled with the control of the first opening. Free space is filled with cotton wool. On cans are labeled from paper label or from polymer materials, self-adhesive.

    Secondary packaging of medicinal product.

    For 10 contour packagings together with the instruction for use are placed in a pack of cardboard for consumer containers.

    On 1 bank together with the instruction on application place in a pack from a cardboard for consumer tare.

    Storage conditions:In the dark place at a temperature of no higher than 25 ° C.
    Shelf life:

    5 years.

    Do not use after the expiration date printed on the package!
    Terms of leave from pharmacies:On prescription
    Registration number:P N003048 / 01
    Date of registration:06.10.2009 / 07.02.2018
    Expiration Date:Unlimited
    The owner of the registration certificate:FARMASINTEZ, JSC (Irkutsk) FARMASINTEZ, JSC (Irkutsk) Russia
    Manufacturer: & nbsp
    Information update date: & nbsp07.05.2018
    Illustrated instructions
      Instructions
      Up