Mycoferon® (Micoferon®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspgel for external use
Composition:

Composition in 1 g:

Active substances: interferon alfa-2b human recombinant not less than 10 000 ME, metronidazole 10 mg, terbinafine hydrochloride 10 mg.

Excipients: disodium edetate 0.5 mg, oleic acid 5 mg, benzyl alcohol 10 mg, macrogol 400 500 mg, carbomer 15 mg, trolamine q.s., water purified to 1 g.

Description:Gel white or white with a yellowish tint of color with a weak specific odor.
Pharmacotherapeutic group:Antifungal agent combined (antifungal agent + antimicrobial and antiprotozoal agent + cytokine)
ATX: & nbsp
  • Terbinafine
    • Pharmacodynamics:

    Mikoferon, a gel for external use - a combined medicinal product, has a local antifungal, antimicrobial, immunomodulating action.

    Terbinafine - has a wide range of antifungal activity. In small concentrations terbinafine has a fungicidal action against dermatophytes (Trychophyton rubrum, T.mentagrophytes, T.verrucosum, T.violaceum, T.tonsurans, Microsporum canis, Epidermophyton floccosum), moldy C.albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity with respect to yeast fungi, depending on their type, may be fungicidal or fungistatic. Terbinafine does not affect the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other medications.

    Metronidazole - synthetic broad-spectrum antimicrobial agent. When topical application is active against anaerobes (Bacteroides spp., Fusobacterium spp., Mobiluncus spp., Peptococcus spp., Peptostreptococcus spp,. Clostridium, Eubacterium, Bacteroides fragilis, Prevotella). Metronidazole is not sensitive to aerobic microorganisms and facultative anaerobes.

    Interferon alfa-2b has a pronounced immunomodulatory effect.

    Pharmacokinetics:

    Not studied.

    Indications:

    Treatment of fungal infections of the skin, including mycosis of the feet (fungus of the foot), fungal lesions of the smooth skin of the body, caused by such dermatophytes as Trichophyton (including, T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum.

    Contraindications:

    Hypersensitivity to the components of the drug, the derivative of nitroimidazole, children under 18 years of age (efficacy and safety of the drug is not established). Pregnancy, the period of breastfeeding.

    Carefully:Hepatic and / or renal failure, alcoholism, oppression of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases.
    Pregnancy and lactation:Contraindicated. Clinical experience of the drug during pregnancy and lactation is absent.
    Dosing and Administration:

    Outwardly. The gel is applied to the affected areas of the skin and adjacent areas with a thin layer, gently rubbing, once a day for 10 days. The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy. If there are no signs of improvement, the diagnosis should be verified.

    Side effects:

    In places where the drug is applied, local reactions are possible: redness, itching, or burning. Allergic reactions.

    Overdose:

    Cases of drug overdose in recommended doses for this method of administration have not been identified. If the drug is accidentally ingested, headache, dizziness, nausea, anorexia, epigastric pain, diarrhea are possible. Treatment: Activated carbon, if necessary, symptomatic therapy.

    Interaction:

    When used simultaneously with warfarin and other indirect anticoagulants, may enhance the anticoagulant effect (increases prothrombin time).Since compatibility studies have not been conducted, it is not recommended to use the drug together with other drugs for external use.

    Special instructions:

    The drug is intended for external use only. Avoid contact with the eyes, nose, mouth, as it can cause irritation and lacrimation. If the product gets into the eyes, they should be rinsed immediately with a copious amount of water, and in case of persistent irritation, consult a physician. When developing allergic reactions, it is necessary to cancel the drug.

    During treatment, general hygiene rules should be followed to avoid re-infection through linens and shoes.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles and maintain moving mechanisms when the drug is used.

    Form release / dosage:Gel for external use.
    Packaging:

    Gel for external use of 5 g, 10 g, 15 g, 30 g in aluminum tubes with bushonami. Each tube, together with instructions for medical use, is placed in a pack of cardboard.

    Storage conditions:

    At a temperature of 2 ° C to 8 ° C. Keep out of the reach of children.

    Shelf life:

    2 years. Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-004377
    Date of registration:18.07.2017
    Expiration Date:18.07.2022
    The owner of the registration certificate:FIRN M, ZAO FIRN M, ZAO Russia
    Manufacturer: & nbsp
    FIRN M, ZAO Republic of Belarus
    Information update date: & nbsp03.10.2017
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