Active substanceMometasoneMometasone
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  • Dosage form: & nbspointment for external use
    Composition:

    In 100 g of ointment:

    active substance: mometasone furoate - 0.1 g;

    Excipients: paraffin (paraffin white soft), beeswax white, propylene glycol monostearate.

    Description:Ointment of white color.
    Pharmacotherapeutic group:Glucocorticosteroid for topical application
    ATX: & nbsp

    R.01.A.D.09   Mometasone

    Pharmacodynamics:

    Mometasone is a synthetic glucocorticosteroid (GCS), which possesses an anti-inflammatory, antipruritic and antiexudative action. SCS induces the release of proteins that inhibit phospholipase A2 and known collectively as lipocortins that control the biosynthesis of inflammatory mediators such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid.

    Pharmacokinetics:

    Absorption of ointment Momat is insignificant. After 8 hours after a single application on intact skin (without occlusive dressing) in the systemic blood stream about 0.7% of the active substance is found. Mometasone intensively metabolized in the liver, is excreted mainly by the kidneys and in an insignificant quantity with bile. The half-life is approximately 5.8 hours.

    Indications:

    Inflammation and itching in dermatoses (psoriasis, atopic dermatitis, seborrheic dermatitis), amenable to glucocorticosteroid therapy, in adults and children older than 2 years.

    Contraindications:

    - Hypersensitivity to any component of the drug or to GCS.

    - Pink acne, perioral dermatitis.

    - Bacterial, viral (Herpes simplex, chickenpox, Herpes zoster) or fungal infection of the skin.

    - Tuberculosis, syphilis.

    - Post-vaccination reactions.

    - Children up to 2 years.

    - Pregnancy (treatment of extensive skin areas, long-term treatment).

    - Lactation period (use in large doses and / and for a long time).

    Carefully:

    Application to the skin and intertriginoznuyu skin, the use of occlusive dressings, as well as treatment of large areas of the skin and / or long-term treatment (especially in children).

    Pregnancy and lactation:

    The safety of the use of mometasone furoate during pregnancy and lactation has not been studied.

    GCS penetrate the placental barrier. Long-term treatment and use of large doses during pregnancy should be avoided due to the threat of adverse effects on fetal development.

    GCS is excreted in breast milk.In the event that the use of GCS is expected in large doses and / or for a long time, breastfeeding should be discontinued.

    Dosing and Administration:

    Outwardly.

    Thin layer of ointment Momat is applied to the affected areas of the skin once a day. The duration of the course of treatment is determined by its effectiveness, as well as the patient's tolerance, the presence and severity of side effects.

    Side effects:

    Rarely - irritation and dry skin, burning sensation, itching, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, signs of skin atrophy, striae, sweating. Less than 1% of cases - the formation of papules, pustules.

    When external forms of SCS are used for a long time and / or for the treatment of large areas of the skin, or with the use of occlusive dressings, especially in children and adolescents, side effects typical of SCS of systemic action, including adrenal insufficiency and Cushing's syndrome, may occur.

    Overdose:

    Symptoms: oppression of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency.

    Treatment: symptomatic, if necessary - correction of electrolyte imbalance, drug withdrawal (with prolonged therapy - gradual abolition).

    Interaction:

    Studies of the drug interaction of the ointment Momat with other drugs was not conducted.

    Special instructions:

    When applied to large areas of the skin for a long time, especially with the application of occlusive dressings, it is possible to develop a systemic action of GCS. Given this, patients should be observed in terms of signs of suppression of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome. You should avoid getting the ointment of Momat in the eyes.

    Propylene glycol, which is part of the preparation, may cause irritation at the site of application. In such cases, you should stop using the Momat ointment and prescribe the appropriate treatment.

    It should be borne in mind that the GCS is able to change the manifestations of certain skin diseases, which can make it difficult to diagnose. In addition, the use of GCS may be the cause of delayed wound healing.

    With prolonged therapy with SCS, sudden discontinuation of therapy can lead to the development of a rebound syndrome, manifested in the form of dermatitis with intense reddening of the skin and a burning sensation.Therefore, after a long course of treatment, the drug should be canceled gradually, for example, by switching to an intermittent treatment regimen before it is completely discontinued.

    Pediatric Use

    The safety and efficacy of mometasone furoate in topical application in children for more than 6 weeks have not been studied.

    Due to the fact that the ratio of surface area and body weight is greater in children than in adults, children are at greater risk of suppressing the function of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome with any local GCS.

    Long-term GCS treatment of children can lead to disruption of their growth and development.

    Children should receive a minimum dose of the drug sufficient to achieve the effect.

    Form release / dosage:

    Ointment for external use 0,1%.

    Packaging:

    5 g and 15 g in an aluminum lip, having a nozzle with a closed end, with a lid having a piercing tip. Each tube together with the instruction for use is placed in a cardboard box.

    Storage conditions:

    In a dry, protected from light place at a temperature of no higher than 25 ° C.

    Do not freeze.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-005532/07
    Date of registration:28.12.2007
    Expiration Date:Unlimited
    The owner of the registration certificate:Glenmark Pharmaceuticals Co., Ltd.Glenmark Pharmaceuticals Co., Ltd. India
    Manufacturer: & nbsp
    Representation: & nbspGLENMARK IMPEX LLCGLENMARK IMPEX LLCRussia
    Information update date: & nbsp24.06.2016
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