Included in the formulation
АТХ:A.05.B.A Preparations for the treatment of liver diseases
Pharmacodynamics:The drug is an antioxidant has antiischemic, membrane, immunomodulatory, hepatoprotective and membrane stabilizing effect. Prevents the death of hepatocytes, reduces the degree of their fatty infiltration and the spread of centrolobular liver necrosis, promotes the regeneration of hepatocytes, normalizes protein, carbohydrate, lipid and pigment exchanges. Increases the synthesis and secretion of bile, normalizes its chemical composition.
The preparation enhances the compensatory activation of anaerobic glycolysis, inhibition reduces oxidation in the Krebs cycle preserving intracellular ATP fund. The drug activates the antioxidant system and inhibits the oxidation of lipids in the ischemic areas. Improves rheological properties of blood (activates the fibrinolytic system). Antioxidant properties are manifested due to the presence in the structure of the molecule of the preparation of the sulfur ion,which is characterized by oxidation-reduction features, and tertiary nitrogen, which binds excess hydrogen ions. The drug reacts with the active forms of oxygen and lipid radicals due to the expressed reducing properties of the thiol group and prevents the occurrence of reactive oxygen species by reactivation of antiradical enzymes - superoxide dismutase, catalase and glutathione peroxidase.
Pharmacokinetics:Bioavailability is 34.6%. Binding to blood proteins does not exceed 10%. With intramuscular injection, the maximum concentration of the drug in the blood is observed after 0.84 hours, with intravenous after 0.1 hours, is metabolized mainly in the liver. The drug accumulates and is excreted mainly (about 30%) by the kidneys. In tangible concentrations, it is found in the large intestine, heart, spleen. The least, about 1-2%, accumulates in the small intestine and lungs.
Indications:- fatty degeneration of the liver;
- cirrhosis of the liver;
- chronic viral hepatitis;
- chronic alcoholic hepatitis of minimal / moderate activity;
- toxic liver damage of various etiologies (alcoholic, viral and medicinal origin).
I.B15-B19.B18.1 Chronic viral hepatitis B without delta-agent
I.B15-B19.B18.2 Chronic viral hepatitis C
XI.K70-K77.K70 Alcoholic liver disease
XI.K70-K77.K71 Toxic liver disease
XI.K70-K77.K73 Chronic hepatitis, not elsewhere classified
XI.K70-K77.K74 Fibrosis and cirrhosis of the liver
Contraindications:- childhood;
- pregnancy;
- lactation;
- hypersensitivity;
- chronic kidney disease;
- deficiency of sucrose / isomaltose, intolerance to fructose, glucose-galactose malabsorption.
Carefully:Hypersensitivity.
Pregnancy and lactation:The drug is contraindicated in pregnant and lactating.
Dosing and Administration:The drug is administered intramuscularly 50 mg of the drug (2 ml of a 2.5% solution) 2-3 times a day, or intravenously 100 mg of the drug (4 ml of a 2.5% solution) at a rate of 2 ml per minute or dropwise 20-30 drops per minute (2 ampules 2.5% solution in 150-250 ml of physiological solution).
The course of treatment is 20-30 days.
From the 5th to the 20th day of treatment the drug can be taken orally 100 mg 3 times a day.
Side effects:From the skin: hyperemia of the skin, itching, urticaria, tingling sensation and hyperemia at the injection site.
From the cardiovascular system: hypertension, arrhythmias, pain in the heart, tachycardia.
From the nervous system: dizziness, weakness, tinnitus.
From the gastrointestinal tract: bloating, nausea, dry mouth.
Allergic reactions: Quincke's edema, hypersensitivity reactions, fever.
Overdose:Not described. When ingesting a large amount of the drug, it is necessary to rinse the stomach.
Treatment: symptomatic.
Interaction:Not described.
Special instructions:Impact on the ability to drive vehicles and manage mechanisms
No data available.