Sodium ascorbate (Natrii ascorbas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Vitamins and vitamin-like remedies

Included in the formulation
АТХ:

B.05.X.C   Vitamins

Pharmacodynamics:

Inhibition of lipid peroxidation; regulation of the transport of hydrogen ions in biochemical reactions. It is an electron donor in the reactions of hydroxylation of proline and lysine in the collagen molecule, carnitine biosynthesis, dopamine hydroxylation (with the formation of norepinephrine) with the participation of dopamine-.beta.-hydroxylase, tyrosine metabolism and amide group addition to peptide hormones (which increases their stability).

Pharmacokinetics:

After oral administration, it is completely absorbed from the digestive tract. Widely distributed in the tissues of the body.

The concentration in the blood plasma is normally about 10-20 μg / ml.

Concentration in leukocytes and platelets is higher than in erythrocytes and in plasma. With deficient states, the concentration in leukocytes decreases later and more slowly and is considered as the best criterion for assessing the deficit than the concentration in the plasma.

Binding to plasma proteins is about 25%.

Indications:

For systemic use: prevention and treatment of vitamin deficiency and Vitamin C vitamin deficiency; ensuring an increased body requirement for vitamin C during growth, pregnancy, lactation, heavy loads, fatigue,in the period of convalescence after prolonged serious diseases; in the winter, with an increased risk of developing infectious diseases.

For intravaginal application: chronic or recurrent vaginitis (bacterial vaginosis, unspecific vaginitis) due to anaerobic flora (due to altered vaginal pH); with the purpose of normalization of the broken microflora of the vagina.

ICD-10

IV.E50-E64.E54   Insufficiency of ascorbic acid

XXI.Z40-Z54.Z54.9   Condition of recovery after unspecified type of treatment

XXI.Z40-Z54.Z54.8   The state of recovery after other treatment

XXI.Z40-Z54.Z54.4   The state of recovery after fracture treatment

XXI.Z40-Z54.Z54.3   The state of recovery after psychotherapy

XXI.Z40-Z54.Z54.2   Condition of recovery after chemotherapy

XXI.Z40-Z54.Z54.1   Condition of recovery after radiotherapy

XXI.Z40-Z54.Z54.0   Condition of recovery after surgery

XXI.Z40-Z54.Z54   Condition of recovery

XXI.Z70-Z76.Z73.0   Overwork

XXI.Z70-Z76.Z73.3   Stress condition, not elsewhere classified

V.F40-F48.F43.1   Post-Traumatic Stress Disorder

Contraindications:

Hypersensitivity.

Carefully:

Children under 18 years of age, pregnancy, breast-feeding.Elderly age, renal and hepatic insufficiency, urolithiasis in the anamnesis.

Pregnancy and lactation:

Category of recommendations FDA C.

The minimum daily requirement for the II and III trimesters of pregnancy is about 60 mg.

Penetrates through the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a newborn can develop ascorbic disease as a withdrawal reaction. Therefore, in pregnancy, do not take in elevated doses, except when the expected benefit exceeds the potential risk.

The minimum daily requirement for lactation (breastfeeding) is 80 mg. Excreted in breast milk. Diet mother, containing an adequate amount, is sufficient to prevent a deficiency in an infant. It is not known whether it is dangerous for a child to use the mother in high doses. Theoretically, this is possible. Therefore, it is recommended not to exceed the nursing mother's maximum daily requirement, except when the expected benefit exceeds the potential risk.

Dosing and Administration:

Applied internally, intramuscularly, intravenously, intravaginally.

For the prevention of deficient conditions - 25-75 mg / day, for treatment of 250 mg / day or more in divided doses.

For intravaginal use, ascorbic acid preparations are used in appropriate dosage forms.

Side effects:

From the side of the central nervous system: headache, fatigue, insomnia.

From the digestive system: stomach cramps, nausea and vomiting.

Allergic reactions: single cases of skin reactions and manifestations on the part of the respiratory system have been described.

From the side of the urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones from calcium oxalate.

Local reactions: with intravaginal application - burning or itching in the vagina, increased mucosal discharge, hyperemia, swelling of the vulva.

Other: a feeling of heat.

Overdose:

Treatment is symptomatic.

Interaction:

With simultaneous use with barbiturates, primidone raises urinary excretion.

With the simultaneous use of oral contraceptives, the concentration in the blood plasma decreases.

With simultaneous use with warfarin, the effects of warfarin may be reduced.

With simultaneous application increases the excretion of iron in patients receiving deferoxamine. With simultaneous use with tetracycline, excretion in the urine increases.

It is possible to increase the concentration of ethinyl estradiol in blood plasma when it is used simultaneously in oral contraceptives.

Special instructions:

It is believed that application in patients with rapidly proliferating and widely disseminated tumors, can aggravate the course of the process. Therefore, it should be used with caution in patients with progressive oncological disease.

Absorption decreases with the simultaneous use of fresh fruit or vegetable juices, alkaline drink.

Instructions
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