Included in the formulation
АТХ:A.01.A.A.01 Sodium Fluoride
Pharmacodynamics:Fluorine ions affect the mineralization of hard tooth tissues during development; form the most stable forms of apatite - fluorapatite. It has an anticarious effect due to a decrease in the cariogenic activity of plaque (especially in children and adolescents), shows bactericidal action. The drug contains malic acid, stimulating salivation. Increased salivation in combination with fluoride has an additional caries prophylactic effect.
Pharmacokinetics:Absorption is fast and complete. Biotransformation in the liver. The maximum concentration is 30-60 minutes. Elimination by the kidneys (50%), in small amounts, the drug is excreted with feces and sweat. At any dose of 50% of the fluoride that is received accumulates in the hard tissues of the tooth and bone tissue. Cumulation in the bones and teeth in the growth stage. Apple acid is almost completely absorbed from the gastrointestinal tract, is metabolized and excreted by the kidneys.
Indications:Symptomatic treatment of oral dryness and elimination of feelings of discomfort caused by insufficient secretion of saliva; prevention of caries in patients suffering from xerostomia.
XI.K00-K14.K11.7 Disorders of salivary gland secretion
Contraindications:Hypothyroidism, individual intolerance, peptic ulcer of the stomach and duodenum in the acute stage, hepatic and / or renal insufficiency, children under 12 years of age, living in the area with a sufficient content of fluoridated water (more than 0.8 mg / l).
Pregnancy and lactation:There is no data on the effect of the drug on the fetus and the baby in pregnant and lactating women, so you should refrain from taking it during pregnancy and lactation.
Dosing and Administration:Dissolve the tablet until complete dissolution. Adults and children over 12 years of age: 6 tablets per day at regular intervals. The dose can be increased by the attending physician, the maximum daily dose is 16 tablets per day.
Side effects:Digestive system: nausea, vomiting, decreased appetite, diarrhea. Nervous system: increased fatigue, headache.
Allergic reactions: rhinitis, eosinophilia, skin rash.
Others: ossification of the attachment sites of tendons and ligaments, hypothyroidism (with prolonged use)
Teeth: fluorosis - a violation of the process of formation and calcification of enamel, the appearance of yellow, brown spots, speckles, increased fragility and abrasion of the teeth.
Overdose:In acute overdose, there is nausea, vomiting, diarrhea, abdominal pain, it is also possible the appearance of lacrimation, hypersalivation, a decrease in appetite. A prolonged overdose can cause fluorosis. For treatment, it is necessary to administer large amounts of liquid and calcium (calcium gluconate or calcium lactate solution, milk) for fluoride precipitation, gastric lavage, the appointment of salt laxatives, intravenous electrolytes, vitamins. And also symptomatic therapy, control of calcium concentration in the blood, hemodialysis.
Interaction:Antacids, preparations containing Ca2 +, Mg2 +, Al3 +, slow down absorption and increase fluoride excretion, reduce its effect; they should be taken no earlier than 2 hours before taking sodium fluoride. Vitamins A and D - development of ectopic calcification.
Special instructions:Patients with blood diseases during the period of therapy require regular monitoring of blood tests.During the systemic application it is necessary to conduct an X-ray examination annually to evaluate the effectiveness of therapy and correction of treatment, as well as for the early detection of fluorosis. When choosing a dose of the drug should take into account the fluoride content in drinking water.