Sodium chloride (Sodium chloride)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspsolution for infusions
Composition:

Active substance: sodium chloride - 9 g

Excipient: water for injection - up to 1 liter

Description:

clear, colorless liquid.

Pharmacotherapeutic group:rehydrating agent.
Pharmacodynamics:

Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes the deficiency of sodium ions in various pathological conditions.

0,9 % the solution of sodium chloride is isotonic with human plasma and is therefore rapidly removed from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:Quickly excreted by the kidneys unchanged.
Indications:

0.9% sodium chloride solution is used to dissolve and dilute drugs, as well as with large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.) hypochloremia and hyponatremia with dehydration, intestinal obstruction, intoxication; for regional perfusion with heparin, antitumor drugs and other drugs.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders,threatening edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:

Decompensated chronic heart failure, chronic renal failure (oligo-, anuria).

Pregnancy and lactation:

A 0.9% solution of sodium chloride can be used for indications during pregnancy and during lactation.

Dosing and Administration:

0.9% solution of sodium chloride is administered intravenously (usually drip). Before administration, the solution is heated to 36-38 ° C. The dose is determined depending on the loss of body fluids, sodium and chloride ions and on average is 1000 ml / day. With large fluid loss and severe intoxication, administration of up to 3000 ml / day is possible. The rate of administration is 540 ml / h; if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg. AT Further, the dosage regimen is adjusted depending on the laboratory

(determination of sodium, potassium, chlorine in the blood and urine, study of acid-base balance, determination of residual nitrogen and creatinine level in the blood).

Side effects:

The introduction of large volumes of 0.9% sodium chloride solution can lead to hyperchloremic acidosis and hyperhydration, as well as hypokalemia.

Overdose:not described
Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect).

When mixed with other drugs, it is necessary to visually control the pharmaceutical compatibility.

Special instructions:

With prolonged administration of large doses of isotonic sodium chloride solution, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

Effect on the ability to drive transp. cf. and fur:The use of the drug does not affect the management of vehicles.
Form release / dosage:

Solution for infusion 0.9%.

100 ml, 150 ml, 200 ml, 300 ml, 400 ml and 450 ml in glass bottles for blood, transfusion and infusion preparations, Corked with rubber stoppers and crimped aluminum caps. A bottle with instructions for use are put in a pack from cardboard.

For hospitals: 35 bottles of 100 ml, 28 bottles of 150 ml and 200 ml or 15 bottles 300 ml, 400 ml and 450 ml together with an equal number of instructions for use are placed in boxes of corrugated cardboard with gaskets, with partitions or with grids ("nests") without preliminary stacking.

Packaging:bottles for blood, transfusion and infusion preparations (1) -package cardboard
bottles for blood, transfusion and infusion preparations (15) - cardboard boxes
bottles for blood, transfusion and infusion preparations (28) - cardboard boxes
bottles for blood, transfusion and infusion preparations (35) - cardboard boxes
Storage conditions:

At a temperature of 5 to 25 ° C.

Keep out of the reach of children.

The non-wetting of the inner surface of the bottles is not a contraindication to the use of the preparation.

Shelf life:

Shelf life 2 years.

Do not use after the expiration date printed on the package.
Terms of leave from pharmacies:On prescription
Registration number:LS-000247
Date of registration:27.01.2010
The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
Manufacturer: & nbsp
Information update date: & nbsp09.09.2014
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