Included in the formulation
АТХ:C.05.B.B.04 Sodium tetradecyl sulfate
Pharmacodynamics:It has surface-active properties, with intravenous administration it provokes inflammation of the endothelium and, as a consequence, the formation of a thrombus. In the future, the thrombus is organized and the affected vein is partially or completely obliterated.
Pharmacokinetics:Not studied.
Indications:Conservative injection-sclerosing treatment of patients with initial and uncomplicated forms of moderately expressed varicose veins of the lower extremities with well-established good patency of deep and communicative veins.A loose type of varicose veins, when the operative removal of all varicose areas is practically impossible.
Complex treatment or postoperative period for sclerotherapy of "disconnected" varicose inflows of subcutaneous veins (1 and 3% solutions).
Varicose veins of the esophagus.
Cutaneous tuberous angiomas in children.
Lipomas.
Cysts of the sebaceous glands.
II.D10-D36.D17.9 Benign neoplasm of adipose tissue of unspecified site
II.D10-D36.D18 Hemangioma and lymphangioma of any site
IX.I80-I89.I85 Varicose veins of the esophagus
XII.L60-L75.L72.1 Trichodermal cyst
IX.I80-I89.I83 Varicose veins
Contraindications:Pregnancy and the period of breastfeeding.Individual intolerance.
Acute superficial thrombophlebitis.
Extensive and pronounced varicose veins with insufficient valves.
Varicose veins due to tumors (abdominal, small pelvis).
Migrating phlebitis.
Obliterating endarteritis.
Phlebosclerosis.
Acute thrombosis and obstruction of deep veins (lower leg, thighs).
Diseases of the heart with the phenomena of decompensation.
Feverish and allergic conditions.
Acute cellulite.
Diabetes.
Toxic hyperthyroidism.
Bronchial asthma.
Oncological diseases.
Acute infection.
Tuberculosis.
Sepsis.
Violation of the cellular composition of the blood.
Acute respiratory or skin diseases.
Common diseases requiring bed rest.
Pregnancy and lactation:The action category for the fetus is FDA-C. The drug is contraindicated for use during pregnancy and the period of breastfeeding.
Dosing and Administration:The drug is administered intravenously.After the first drops of blood appear from the needle, the patient is placed on his back, raising his leg at an angle of 30-40 °. After the end of the site, the puncture is closed with a bandage, the leg is left in a raised position and bandaged with an elastic bandage from the toes to the upper third of the thigh. It is important that after the procedure the patient vigorously go for at least 3-4 hours. This is necessary to prevent possible damage to the endothelium of the deep veins with subsequent thrombosis.
For the treatment of mild varicose veins or soft, easily falling nodes, a 1% solution is prescribed, with large knots with thickened thick walls, and in the absence of an efficacy of 1% solution, a 3% solution is recommended.
In one session, 2-6 points are introduced (distances between the points of the injections are not less than 6-12 cm), 0.5-2 ml per each (preferably 1 ml).
With extensive varicose, the procedure is repeated 2-10 times at intervals of 3-5 days with an increase in the number of injection sites and an increase in the total dose for 1 session.
Side effects:There may be redness, pain and rashes at the injection site. And also a burning sensation and soreness in the area of sclerosed nodes and venous trunks, residual pigmentation of the sclerosing segment of the vein,development of soft tissue necrosis, intra-varicose hematomas, formation of a scab, ascending phlebitis with thrombophlebitis. Among the systemic reactions, nausea and vomiting, headache and thrombosis of pulmonary veins (possible fatal outcome), systemic infections, allergic reactions, as well as complications caused by ingestion of the drug in the artery, obliteration of the leading vessel (amputation of the limb), embolism (even after 4 month after the procedure).
Interaction:It is not recommended to combine with oral contraceptives. It is not recommended simultaneous use with heparin.
Special instructions:Avoid extravasal (paravenous) and intra-arterial administration.