Intravenous or oral. The patient is given an empty stomach to take 0.185-0.370 MBq of the drug dissolved in 30-50 ml of water, supplementing the introduction with flushing from the walls of the used dishes. Thyroid radiometry is carried out after 2, 4 and 24 hours. Simultaneously, radiometry is subjected to a phantom of the thyroid gland with an equal number of indicators taken ill.The result is expressed as a percentage of the accumulation of the radionuclide from the administered amount and is calculated by the formula:
A = (B-Nf) / (C-Nf) x 100%
where A is the accumulation of a radionuclide in the thyroid gland,%,
B - the content of iodine-123 in iron, imp / min,
C - content of iodine-123 in the standard, imp / min,
Nf - background, imp / min
To conduct gammatographic examinations, a patient on an empty stomach is given or accepted intravenously 8.0 - 10.0 MBq of the drug. If necessary, the preparation is diluted with a certain amount of saline. The optimal time for a thyroid scan is from 2 to 6 hours after the administration of the drug. Research of the functional state and topography of the thyroid gland should be conducted no earlier than 1 month after the discontinuation of the ingestion of substances and medications containing iodine or affecting the iodine-accumulating function of the thyroid gland. These include: stable iodine (including contact with the skin or mucous membranes), iodine-containing and iodinated products, radiocontrast agents, iodine-containing multivitamin preparations (Centrum, Vitrum, Unicap, Multi-tabs and others), fluorine, bromine, triiodothyronine, thyroxine, thyroidin, 6-methylthiouracil and other similar antithyroid drugs, as well as pituitary, sex and steroid hormones.The degree and duration of the effect of organic iodine compounds is determined by the rate of their decay in the body and the amount of iodine liberated.
With the aim of determination of the level of protein-bound iodine in a patient after 48 hours a blood sample (8-10 ml) is taken from the ulnar vein. After centrifugation, 4-5 ml of plasma is transferred to a tube and the protein is separated by adding 3% of 10% trichloroacetic acid solution in a volume equal to the volume of the plasma to be analyzed, followed by centrifugation at 2000 rpm for 10 minutes. The resulting precipitate is dissolved to the original volume of the plasma in a 2 M solution of sodium or potassium hydroxide and the radiometry is run in a well counter in parallel with the standard. The volume of the standard should be equal to the volume of plasma taken for radiometry.
The percentage of protein-bound iodine (A) is calculated by the formula:
A = (B - Nf) x 1000 x 100 / C x (D - Nf)% / l, where
The content of iodine-123 in the sample, imp / mip; C is the volume of plasma taken for analysis, ml; D - iodine-123 content in the standard, imp / min; Nf - background, imp / min.
The normal level of protein-bound iodine is no more than 0.3% / l.
Radiation loads on the organs and entire body of the patient when using the drug
"Sodium iodide, 123I, isotonic "
| Organs | Absorbed dose, mGy / MBq |
| Stomach | 0,0069 |
| Red marrow | 0,0094 |
| Lungs | 0,0061 |
| Bladder | 0,0094 |
| Liver | 0,0067 |
| Pancreas | 0,0076 |
| Kidneys | 0,011 |
| Spleen | 0,007 |
| Small intestine | 0,0085 |
| Colon | 0,0097 |
| Thyroid | 0,0051 |
| Eggs | 0,0069 |
| Ovaries | 0,0098 |
| The whole body (effective equivalent dose, mSv / MBq) | 0,013 |