Active substanceLidocaine + Metronidazole + MiconazoleLidocaine + Metronidazole + Miconazole
Similar drugsTo uncover
  • Neo-Penotran® Forte L
    suppositories the vagina. 
  • Dosage form: & nbsp
    Vaginal suppositories
    Composition:

    Each vaginal suppository contains:

    Active substances:

    Metronidazole (micronized) 750.00 mg;

    Miconazole nitrate (micronized) - 200.0 mg;

    Lidocaine - 100, 0 mg.

    Excipients: vitepsol - 1436.75 mg.

    Description:

    Vaginal suppositories in the form of a flat body with a rounded end, from white to slightly yellowish in color.

    View on longitudinal and horizontal sections: homogeneous mass from white to slightly yellowish color.

    Pharmacotherapeutic group:Antimicrobial agent combined (antimicrobial and antiprotozoal agent + antifungal agent)
    ATX: & nbsp

    G.01.A.F.20   Combinations of imidazole derivatives

    Pharmacodynamics:

    Neo-Pentotrans® Forte L is a combination of metronidazole, miconazole and lidocaine.

    Metronidazole, a 5-nitroimidazole derivative, is an antiprotozoal drug with an antimicrobial effect. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa.The restored 5-nitro group of metronidazole interacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria and protozoa. It is active against Trichomonas vaginalis, Gardnerella vaginalis, Gardia lamblia, and obligate anaerobes Bacteroides spp. and some gram-positive organisms.

    Miconazole is a derivative of imidazole, has an antifungal effect against dermatophytes, yeast fungi, and antibacterial action against gram-positive bacteria. When intravaginal application is active mainly in relation to Candida albicans. The mechanism of action is to suppress the biosynthesis of ergosterol in fungi and to change the composition of lipid components in the membrane, which leads to the death of fungal cells. It is fungicidal and bactericidal.

    Lidocaine stabilizes the neuronal membrane, inhibiting the ion flows necessary for the generation and carrying out of impulses, thereby providing local anesthetic action.

    Pharmacokinetics:With intravaginal application, systemic absorption of active components is negligible.
    Indications:Treatment of vaginitis caused by pathogens of genera Candida, Trichomonas and Gardnerella (vaginal candidiasis, trichomonas vulvovaginitis, bacterial vaginosis), mixed vaginal infection.
    Contraindications:

    - Hypersensitivity to imidazoles, to nitroimidazole derivatives, as well as to other components of the drug;

    - Organic lesions of the central nervous system (CNS), incl. epilepsy;

    - Violations of coordination of movements;

    - Leukopenia (including in the anamnesis);

    - Liver failure;

    - Pregnancy;

    - The period of breastfeeding;

    - Children under 18 years.

    Carefully:

    - Diabetes.

    - Disturbance of microcirculation.

    - Porphyria.

    Dosing and Administration:

    Intravaginal.

    Suppositories should be administered in a prone position deep in the vagina.

    The drug is used for 1 vaginal suppository at night for 7 days. With relapsing disease or vaginitis, resistant to other treatment, it is possible to extend the course of treatment to 14 days.

    Older patients

    When using the drug elderly patients (over 65 years of age) do not need to change the dosage regimen.

    Side effects:

    Usually the drug Neo-Pentotran® Forte L is well tolerated.

    When using the drug, the following side effects are possible:

    Disorders from the gastrointestinal tract: diarrhea, constipation, loss of appetite, nausea, vomiting,inflammation of the oral mucosa, a violation of taste sensations, dry mouth, pancreatitis (reversible cases), discoloration of the tongue / "lipped tongue".

    Impaired nervous system: headache, fatigue, dizziness, convulsions, peripheral sensory neuropathy, reported on the development of encephalopathy (for example, confusion) and subacute cerebellar syndrome (impaired coordination and synergy of movements, ataxia, dysarthria, gait disorders, nystagmus and tremor) that occur after withdrawal Metronidazole.

    Disorders of the psyche: psychotic disorders, including confusion, hallucinations, mood suppression, irritability, increased excitability.

    Disturbances on the part of the organ of sight: transient visual impairment, such as diplopia, myopia, vagueness of the contours of objects, decreased visual acuity, impaired color perception, neuropathy / optic neuritis.

    Violations of the blood and lymphatic system: agranulocytosis, leukopenia, neutropenia and thrombocytopenia.

    Disturbances from the liver and bile ducts: an increase in the activity of "liver" enzymes, the development of cholestatic or mixed hepatitis and hepatocellular liver damage, sometimes accompanied by jaundice.

    Disturbances from the skin and subcutaneous tissues: a rash, itchy skin, skin hyperemia, urticaria, pustular skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis.

    Disorders from the kidneys and urinary tract: it is possible to stain urine in brownish-red color, dysuria, polyuria, cystitis, urinary incontinence.

    Immune system disorders: angioedema, anaphylactic shock.

    General disorders and disorders at the site of administration: fever, nasal congestion, arthralgia, weakness, burning sensation or irritation of the penis in the sexual partner, burning sensation or frequent urination, vulvitis (itching, burning pain or hyperemia of the mucosa in the external genital area).

    Laboratory and instrumental data: flattening of the T wave on the electrocardiogram (ECG).

    If these side effects develop, discontinue use and consult a doctor.

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

    Overdose:When using the drug in accordance with the instructions for use, an overdose is unlikely. With occasional ingestion, symptoms may occur: nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste in the mouth, ataxia, dizziness, paresthesia, peripheral neuropathy, convulsions, leukopenia, staining of urine in a dark color. Treatment: gastric lavage, symptomatic and maintenance therapy are performed.
    Interaction:The drug interaction of the Neo-Pentotran® Forte A drug was not studied in vaginal application. Despite the fact that the active component metronidazole, part of the vaginal suppositories is slightly absorbed, interactions with disulfiram, ethanol, indirect anticoagulants (warfarin), lithium preparations, cyclosporine, cimetidine, drugs that induce enzymes of microsomal oxidation in the liverphenobarbital, phenytoin), fluorouracil, busulfan, nondepolarizing muscle relaxants (vecuronium bromide).
    Special instructions:

    The use of suppositories can reduce the reliability of mechanical contraception (latex-containing condoms, vaginal diaphragms). During treatment it is recommended to select reliable methods of contraception.

    Alcohol intake should be excluded during treatment with the drug, and also within 3 days after the application of the last dose.

    During treatment it is necessary to abstain from sexual intercourse. It is necessary to simultaneously treat a sexual partner.

    If the vagina is strongly irritated, treatment should be stopped. Treatment does not stop during menstruation.

    After therapy with trichomoniasis, control tests should be performed for 3 consecutive cycles before and after menstruation.

    It is necessary to take into account that metronidazole can immobilize treponemy, which leads to a false positive test of Nelson.

    Read the instructions carefully before using the product. Keep the manual, it may be needed again. If you have any questions, contact your doctor. The medicinal product that you are being treated is intended for you personally, and it should not be passed on to others,because it can cause them harm even if there are those Dice symptoms that you have.

    Effect on the ability to drive transp. cf. and fur:It is recommended to be cautious, since a possible negative impact on the ability to drive a motor vehicle and manage complex machinery can not be ruled out.
    Form release / dosage:Suppositories are vaginal, 100 mg + 750 mg + 200 mg.
    Packaging:For 7 suppositories in a blister of PVC / PE. One blister, along with instructions for use, is placed in a cardboard pack.
    Storage conditions:Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
    Shelf life:3 years. Do not use the product after the expiration date printed on the package!
    Terms of leave from pharmacies:On prescription
    Registration number:LP-000486
    Date of registration:01.03.2011 / 10.04.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:Exeltys Khelskea S.L.Exeltys Khelskea S.L. Spain
    Manufacturer: & nbsp
    Representation: & nbspExeltys Khelskea S.L.Exeltys Khelskea S.L.Spain
    Information update date: & nbsp19.06.2018
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