NeoGep® (NeoHep)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Similar drugsTo uncover
Dosage form: & nbspcapsules
Composition:

Composition per one capsule:

Active substance: NeoHep (1- (4-bromophenyl) violuric acid) - 500.0 mg.

Excipients: Lactose monohydrate; giprolose; magnesium stearate; silicon dioxide colloid (aerosil).

Hard gelatin capsule № 00: Gelatin; titanium dioxide [E 171]; dye quinoline yellow [E 104]; dye sunset sunset yellow [E 110].

Description:

Yellow solid opaque gelatin capsules № 00.

Contents of the capsules: powder or granulate white with a yellowish tinge or light yellow color with a weak specific odor.
Pharmacotherapeutic group:Hepatoprotective agent
ATX: & nbsp
  • Preparations for the treatment of liver diseases
    • Pharmacodynamics:

    Hepatoprotective agent, reduces dystrophic changes in the liver parenchyma. In acute and chronic lesions of the liver reduces the manifestations of cytolysis, normalizes the pigment-forming and antitoxic function of the liver, reduces the phenomenon of cholestasis, reduces the inflammatory response.

    Pharmacokinetics:

    The relative bioavailability is about 73%. The maximum concentration of 1- (4-bromophenyl) -violuric acid in the blood plasma is observed 6 hours after the administration of the drug. The time of drug retention in the body is 11 hours. The magnitude of the apparent stationary volume of the distribution - about 116 ml / kg.The half-life is about 6 hours. It is excreted mainly by the kidneys.

    Indications:

    Acute hepatitis, chronic hepatitis, liver cirrhosis, fatty liver degeneration of various etiologies, toxic liver damage, including alcohol, viral and medicinal (antibiotics, antitumor, antituberculosis, antiviral drugs, tricyclic antidepressants, oral contraceptives).

    Contraindications:

    - Hypersensitivity to 1- (4-bromophenyl) violuric acid or other components of the drug;

    - children under 18 years of age (due to lack of clinical research data);

    - lactose intolerance, congenital lactase deficiency, glucose-galactose malabsorption (the preparation contains lactose).

    Carefully:

    Violation of hematopoiesis.

    Pregnancy and lactation:

    The use during pregnancy and during breastfeeding is contraindicated (due to the lack of data from clinical studies).

    Dosing and Administration:

    Dosing and Administration Inside, 30 minutes before eating, without chewing and drinking with a sufficient amount of liquid.

    The drug is taken in a dose of 2000 mg 2 times a day, in the morning and in the evening (daily dose of 4000 mg / day).

    The course of treatment is 7 days.

    Side effects:

    Allergic reactions (including urticaria), a change in the color of urine to pink-violet.

    In clinical studies, the following were also observed adverse reactions: feeling of heaviness in the epigastrium, belching, heartburn, sleep disorders, accelerated erythrocyte sedimentation rate, anemia, leukocyte shift left lymphocytosis.

    Overdose:

    Cases of overdose are not registered.

    In case of an overdose, symptomatic treatment is performed.

    Interaction:

    Special studies of the interaction of NeoGep® were not conducted.

    Special instructions:

    Pink-purple staining of urine may mask the symptoms of hematuria, so in the case of staining of urine and the simultaneous appearance of specific symptoms of urinary system diseases, you need to make a differential diagnosis to rule out hematuria. It is necessary to inform the patient in advance about a possible change in the color of urine, which is not clinically important and disappears after withdrawal preparation.

    Effect on the ability to drive transp. cf. and fur:

    There is no evidence of the effect of NeoGep® on the ability to drive vehicles and work withmechanisms.

    Form release / dosage:

    Capsules 500 mg.

    Packaging:

    10 capsules per contour cell package.

    6 contour packs with instructions for use in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-004447
    Date of registration:01.09.2017
    Expiration Date:01.09.2022
    The owner of the registration certificate:Virpharm, LLCVirpharm, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp28.09.2017
    Illustrated instructions
      Instructions
      Up