NooKam - instructions for use, doses, side effects, contraindications

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Dosage form: & nbspCapsules.

Composition:

Active components - piracetam 0.4 g, cinnarizine 0.025 g.

Excipients - lactose (sugar milk), silicon dioxide colloid (aerosil), magnesium stearate.Gelatin capsule - gelatin pharmaceutical, glycerol, propylparahydroxybenzoate (nipazol), methylparahydroxybenzoate (nipagin), sodium lauryl sulfate, purified water, blue diamond dye.

Description:

Capsules № 0 of white color with a lid of blue color. The contents of the capsules are white to white powder with a creamy shade of color.

Pharmacotherapeutic group:Nootropic agent.

Pharmacodynamics:

Combined drug with pronounced antihypoxic, nootropic and vasodilating effect.

Piracetam activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia, improves transmission of nerve impulses in neurons of the central nervous system, improves regional blood flow in the ischemic zone.

Cinnarizine is a selective blocker of slow calcium channels, inhibits the entry of calcium ions into cells and reduces their content in the depot of the plasmolemma, lowers the tone of the smooth muscles of arterioles, reduces their response to biogenic vasoconstrictors (epinephrine, norepinephrine, dopamine, angiotensin, vasopressin).Has a vasodilating effect (especially with respect to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces the viscosity of the blood.

Pharmacokinetics:

The drug is quickly and completely absorbed in the gastrointestinal tract. The maximum concentration of pyracetam in the plasma is created in 2-6 hours. The maximum concentration in liquor is 2-8 hours. Bioavailability is 100%. Plasma does not bind to proteins. Penetrates into all organs and tissues, passes the placental barrier.

Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, the cerebellum and basal ganglia. It is not metabolized. After 30 hours more than 95% is excreted by the kidneys.

The maximum concentration of cinnarizine in plasma is created in 1-4 hours. With plasma proteins binds to 91%. It is actively and completely metabolized. The half-life is 4 hours.1/3 of metabolites is excreted in urine, 2/3 - with feces.

Indications:

Violation of cerebral circulation (atherosclerosis of cerebral vessels, ischemic stroke, recovery period after hemorrhagic stroke, encephalopathy of various origins); intoxication, brain trauma and other diseases of the central nervous system, accompanied by a decrease in intellectual-mnestic functions (memory, attention, mood); psychoorganic syndrome with predominance of asthenia and adynamia, asthenic syndrome; labyrinthopathy, Meniere's syndrome; lag of intellectual development in children, prevention of migraine and kinetosis.

Contraindications:

Individual intolerance, severe violations of the liver and / or kidney function, parkinsonism, pregnancy, lactation, children under 5 years.

Carefully:

Parkinson's disease.

Dosing and Administration:

Adults: 1-2 capsules 3 times a day, for 1-3 months (depending on the severity of the disease), treatment 2-3 times a year.

Children from the age of 5: 1-2 capsules 1-2 times a day, for 1-3 months.

Side effects:

Irritability, sleep disturbances, nausea, dyspepsia, headache, allergic reactions.

Overdose:

Interaction:Strengthens the effects of nootropic, adaptogenic, hypotensive drugs, drugs that depress the central nervous system (including ethanol). Improves the tolerability of antipsychotic drugs and tricyclic antidepressants. Weaken the effect of hypertensive drugs.

Special instructions:

The drug should be given cautiously to people with liver and / or kidney disease. In the case of mild and moderate renal failure (especially if creatinine clearance is less than 60 ml / min), the therapeutic dose should be reduced or the intervals between doses should be increased. In persons with impaired liver function, control of liver enzymes is necessary.

During treatment, alcohol should be avoided.

The drug should be carefully prescribed for Parkinson's disease.

The drug may cause a positive reaction when controlling doping drugs in athletes.

Effect on the ability to drive transp. cf. and fur:

During treatment, care should be taken when driving vehicles and working with moving machinery.

Form release / dosage:

Capsules, 400 mg + 25 mg

Packaging:

10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil.

For 50 or 100 capsules in a can of polymer or a bottle of polymer.

For 50 or 100 capsules in a can of vitreous OC with a screw neck.

5, 6 or 10 contour mesh packages, a jar or bottle together with the instruction for use is placed in a cardboard package

Storage conditions:

In a dry place, at a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Shelf life:

2 years

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-007063/09

Date of registration:07.09.2009

The owner of the registration certificate:CAMELIA NPP, LLC CAMELIA NPP, LLC Russia

Manufacturer: & nbsp

CAMELIA NPP, LLC Russia

Information update date: & nbsp10.09.2015

Illustrated instructions

Instructions

NooCam (NooCam)