Omega-3 triglycerides [EPA / DHA = 1.5 / 1 - 50%] (Omega-3-triglycerides [EPA / DHA = 1.5 / 1 - 50%])

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Lipid-lowering drugs

Included in the formulation
  • Vitrum® cardio OMEGA-3
    capsules inwards 
    Unipharm, Inc.     USA
  • Eifitol
    capsules inwards 
       
    • АТХ:

    C.10.A.X.06   Omega-3 triglycerides, including other esters and acids

    Pharmacodynamics:

    Inhibits acyl-CoA-1,2-diacylglycerol acyltransferase, esterification of higher fatty acids. Enhances peroxisomal β-oxidation of triglycerides in the liver.

    A combined preparation containing polyunsaturated fatty acids of the omega-3 family - eicosapentaenoic acid, docosahexaenoic acid and vitamin E.

    Has a therapeutic effect in the violations of lipid metabolism, due to severe hypertriglyceridemia, has anti-inflammatory effect. Promotes normalization of content low density lipoprotein and very low density lipoproteins, a change in the liquid properties of cell membranes, and an increase in the functional activity of membrane receptors, which improves the lipid-cellular interaction of lipoproteins with enzymes and the metabolism of lipoproteins. Antiaggregant effect of the drug is associated with the change under its influence of the lipid composition of cell membranes, including erythrocyte membranes,characterized by a decrease in the content of arachidonic acid in them and an increase in the level of eicosapentaenoic acid. As a result, there is a decrease in the synthesis of thromboxane A2 and other two-unsaturated eicosanoids (arachidonic acid derivatives) that enhance platelet aggregation and increase synthesis from eicosapentaenoic acid thromboxane A3 and other tri-unsaturated eicosanoids, which do not possess a proaggregant effect.

    This complex of essential polyunsaturated fatty acids is used to normalize lipid metabolism and reduce the risk of developing atherosclerosis.

    Vitamin E has antioxidant activity, participates in tissue respiration and other important processes of tissue metabolism; protects cells and tissues from the damaging effect of excessive amounts of free radicals and products of lipid peroxidation.

    Pharmacokinetics:

    It is better absorbed in persons younger than 50 years and women. Metabolized by replenishment of peripheral lipid stocks, oxidation to ensure energy needs, inclusion in the composition of cell membranes.

    Indications:

    - prevention of conditions caused by dyslipidemia (violation of lipid metabolism);

    - hypovitaminosis E, D;

    - complex therapy of lipid metabolism disorders, in combination with diet, prescription of statins, antiaggregants.

    ICD-10

    IV.E50-E64.E56.0   Insufficiency of vitamin E

    IV.E70-E90.E78   Disorders of lipoprotein metabolism and other lipidemia

    IV.E70-E90.E78.5   Hyperlipidemia, unspecified

    Contraindications:

    - hypersensitivity;

    - childhood;

    - exacerbation of chronic cholecystitis;

    - exacerbation of chronic pancreatitis;

    - exacerbation of diseases of the hepatobiliary system;

    - cholelithiasis;

    - pathological conditions, including hemorrhagic syndrome.

    Carefully:

    No data.

    Pregnancy and lactation:

    Category FDA - C. There are no adequate and well-controlled studies. During pregnancy and during breastfeeding should be used only as prescribed by the doctor.

    Dosing and Administration:

    Inside, 30 minutes after eating, washed down with water. Adults: for prophylactic purposes - 1 capsule per day, with a therapeutic - 2-3 capsules per day. The course of treatment - at least 3 months. Repeated courses - on the advice of a doctor.

    1 capsule contains 1000 mg of the drug.

    Dyslipidemia: 2-3 capsules per day, treatment course at least 3 months.

    Hypovitaminosis E, D: 1 capsule per day.

    Side effects:

    From the gastrointestinal tract: dyspepsia, gastrointestinal bleeding, possible a sense of taste of fish, belching with a taste of fish in the first days of intake, a lax effect.

    From the skin: rash, hives.

    From the respiratory system: epistaxis.

    From the cardiovascular system: lowering of blood pressure.

    From the immune system: allergic reactions.

    From the nervous system: dizziness, headache, dysgeusia.

    From the side of metabolism: gout, hyperglycemia.

    Overdose:

    Symptoms: manifestations of hypervitaminosis - pain in the epigastric region, dyspeptic phenomena (nausea, vomiting, diarrhea); with prolonged use in high doses may exacerbate chronic pancreatitis.

    Treatment: withdrawal of the drug, symptomatic therapy

    Interaction:

    At simultaneous application with oral anticoagulants there is a risk of an increase in bleeding time.

    Drugs that aggravate hypertriglyceridemia, weaken the effect of the drug.

    Potentiating Effects simvastatin, atorvastatin at a dose of 4 grams per day.

    Special instructions:

    While taking the drug, do not take other medicines that contain vitamin E.

    Do not exceed the recommended daily dose.

    Impact on the ability to drive vehicles and manage mechanisms

    Studies have not been conducted. May cause dizziness, use caution.

    Instructions
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