Omnopon increases the pain threshold, inhibits conditioned reflexes and causes euphoria has mild sedative and central antitussive effect, increases the tonus of the vagus nerve center, stimulates the vomiting center, depresses the respiratory center, causing constriction of the pupil due to the activation center oculomotor nerve, attenuates intestinal peristalsis,inhibits the secretory activity of the glands of the gastrointestinal tract. Somewhat reduces the basal metabolic rate and body temperature, stimulates the release of antidiuretic hormone. With subcutaneous administration of Omnepona, the analgesic effect develops in 10-15 minutes and persists for 3-5 hours. The main pharmacological properties of Omnepone are due to the morphine contained in it. Morphine - an agonist of predominantly mu-opioid receptors, activates the endogenous antinociceptive system and thus disrupts the interneuronal transmission of pain impulses at various levels of the central nervous system, and also changes the emotional color of the pain, affecting the higher parts of the brain.
Morphine increases the threshold of pain sensitivity with stimuli of different modalities, inhibits conditioned reflexes, has euphoric and moderate hypnotic activity, increases the tone of the center of the vagus nerve. It can stimulate chemoreceptors of the start-up zone of the vomiting center and cause nausea and vomiting, depress respiratory and vomiting centers, cause pupillary narrowing due to activation of the center of the oculomotor nerve, increase bronchial tone and smoothing(intestines, bile ducts, bladder), increases the contractile activity of the myometrium, weakens the intestinal motility, inhibits the secretory activity of the glands of the gastrointestinal tract. Somewhat reduces the basal metabolism and body temperature, stimulates the release of antidiuretic hormone. Causes the widening of the peripheral blood vessels and the release of histamine, which can lead to lower blood pressure, reddening of the skin, increased sweating, reddening of the protein coat of the eyes. Enhances the influence on the central nervous system of means for general anesthesia, hypnotics, sedatives, H blockers1 histamine receptors with a central component of action, anxiolytic, antipsychotic and antidepressant drugs.
Papaverin is a spasmolytic agent that exerts an antihypertensive effect, reduces tone and relaxes the smooth muscles of the internal organs and vessels. Due to the content of papaverine, Omnipon is to a lesser extent than morphine, causes spasms of smooth muscles of internal organs.
Codeine is a natural narcotic analgesic from the group of opioid receptor agonists. Anesthetic activity is caused by the excitation of opioid receptors in various parts of the central nervous system and peripheral tissues, leading to stimulation of the antinociceptive system and changes in emotional perception of pain.
Thebaine is the smallest in number of components of the drug. According to its chemical structure, thebaine is similar to morphine and codeine. Tebain has an analgesic effect, affecting opioid receptors in the central nervous system. According to its pharmacological properties, thebaine differs from morphine and codeine in that it produces an exciting, not depressing, effect on the nervous system. Tebain in small doses has a weak hypnotic effect. Potentiates the effect of codeine and morphine.
Noscapine is an alkaloid poppy dormant, a benzylisoquinoline derivative; is an agonist predominantly σ-opioid receptors, has almost no analgesic properties, has antitussive effect. Noscapin's Eyehas a spasmolytic effect on smooth muscle.Has a potentiating effect on the spasmolytic activity of papaverine.