The incidence of adverse reactions listed below was determined by the following criteria: very often (not less than 1/10), often (more than 1/100, less than 1/10); infrequently (more 1/1000, less than 1/100); rarely (more than 1/10000, less than 1/1000); very rarely (less than 1/10000), including individual messages.
The most common adverse reactions: headache - up to 9%; constipation - up to 5%.
Infrequently observed adverse reactions:
from the cardiovascular system: tachycardia, bradycardia, extrasystoles, myocardial ischemia, sinus tachycardia, sinus arrhythmia, supraventricular extrasystoles, lowering of blood pressure (BP), increased blood pressure, lengthening of the interval QT, varicose veins, varicose veins veins;
from the nervous system: headache, dizziness, drowsiness, insomnia, paresthesia, peripheral sensory neuropathy, anxiety, euphoria;
from the digestive system: constipation, diarrhea, abdominal pain dry mucosa membranes of the mouth, flatulence, anorexia, hiccough;
with the side of the urinary system: retention of urine;
from the skin and skin appendages: allergic dermatitis, itching, rash;
from the musculoskeletal system: arthralgia;
from the senses: increased sensitivity of the eyes - irritation, diplopia, amblyopia, impaired coordination of movements, tinnitus;
change laboratory indicators: increased activity of "hepatic" transaminase, hypo- or hyperkalemia, hypocalcemia, hyperglycemia, hyperbilirubinemia, glucosuria, metabolic acidosis;
Other: increased fatigue, weakness, increased body temperature, hot flashes - a feeling of "heat", flu-like syndrome.
Very rare reactions occur at the injection site (burning, tightening, pain).