Ornidazole - instructions for use, dose, side effects, contraindications

Excipients - lactose (milk sugar), microcrystalline cellulose, calcium phosphate dihydrate, citric acid, impellose (croscarmellose sodium), calcium stearate.

Description:

Tablets are white or white with a yellowish tint of color, flat, oblong in shape.Presence of marble is admissible.

Pharmacotherapeutic group:An antiprotozoal agent.

ATX: & nbsp

G.01.A.F.06 Ornidazole

Pharmacodynamics:

Antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of ornidazole with intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of ornidazole reacts with DNA cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Active with respect to Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolitica, Lamblia spp., as well as obligate anaerobes Bacteroides spp. (including Bacteroides fraglis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P. bivia, P. buccae, P.disiens), and some Gram-positive microorganisms (Eubacterium spp., Clostridium). Orniferous microorganisms are not sensitive to ornidazole.

Pharmacokinetics:

Metabolized in the liver by hydroxylation, oxidation and glucuronation. With intravaginal application, the drug is excreted: kidneys - 60-80% (20% of this amount - unchanged), intestine -10-20%.

Indications:

- Urogenital trichomoniasis;

- nonspecific vaginitis of different etiology, confirmed by clinical and microbiological data;

prevention of infections caused by anaerobic bacteria during surgery on the colon and in gynecology.

Contraindications:

Hypersensitivity, pregnancy (I trimester), the period of breastfeeding.

Carefully:

Pregnancy (II - III trimester), leukopenia in the anamnesis.

Dosing and Administration:

With trichomoniasis: intravaginally on 1 vaginal tablet 500 mg daily before bedtime for 5 days. A 500 mg tablet is prescribed as a part of complex therapy with Ornidazole® preparation, film-coated tablets.

With nonspecific vaginitis; Inveraginally on 1 vaginal tablet 500 mg daily before bedtime for 6-7 days.

To sanitize the vagina before endoscopic operations: intravaginally

1 vaginal tablet 500 mg daily before bedtime for 6 days.

Vaginal tablet in all these cases should be injected deep into the vagina after hygienic treatment of the external genitalia.

Side effects:

Local reactions: rarely - a burning sensation, local irritation, dryness of the vagina (especially at the beginning of treatment). In some cases, allergic reactions are possible.

Overdose:

Symptoms: epileptiform cramps, depression, peripheral neuritis.

Treatment: symptomatic (diazepam - with convulsions).

Interaction:

Strengthens the effect of anticoagulants coumarinic series, prolongs the miorelaksiruyuschee effect of vecuronium bromide.

Compatible with ethanol (does not inhibit acetaldehyde dehydrogenase), unlike other imidazole derivatives (metronidazole).

Special instructions:

When treating trichomoniasis, simultaneous treatment of sexual partners should be carried out.

Form release / dosage:Vaginal tablets 500 mg.

Packaging:

3 tablets per contour mesh package made of polyvinyl chloride light barrier film and aluminum foil.

3 or 6 tablets per can of polymer.

1 or 2 contour mesh packages or each jar together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

List B. In a dry place inaccessible to children, protected from light at a temperature of no higher than 25 ° C.

Shelf life:

2 of the year. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-003088/08

Date of registration:24.04.2008

The owner of the registration certificate:VERTEKS, AO VERTEKS, AO Russia

Manufacturer: & nbsp

VERTEKS, AO Russia

Representation: & nbspVERTEKS CJSC VERTEKS CJSC Russia

Information update date: & nbsp20.05.2015

Illustrated instructions

Instructions

Ornidazole (Ornidazole)