Ovitrel® (Ovitrelle®)

With anovulatory or oligovulatory infertility for induction of ovulation and luteinization at the end of stimulation of follicle growth:

Ovitrel® at a dose of 250 μg (the contents of 1 syringe or 1 syringe-pen) is injected once 24-48 hours after reaching the optimum level of development of the follicle. It is recommended to have sex on the day of Ovitrel® administration and on the next day.

Recommendations for the self-administration of Ovitrel®.

Self-introduction is possible only by patients who have received appropriate training and have the opportunity to seek advice from a specialist doctor.

When self-administered, the patient should carefully read and strictly follow the instructions below for the administration of the drug:

Before the introduction:

1. Wash your hands. It is important that your hands and the items that you use are clean.

2. Prepare a clean surface and lay out on it everything you need for injection:

1. two tampons moistened with alcohol (not included in the package);

2. one syringe with the drug or one syringe-pen and a needle for injection.

For a syringe:

1. Introduction of injection: Immediately swipe injection:

Choose a site for injection in accordance with the recommendations of your doctor or nurse (stomach, front of the thigh). Wipe the selected area with a swab with alcohol. Strongly tighten the skin with your fingers and with a short, vigorous movement, aim the needle at an angle 45° - 90 ° in the skin fold. Conduct a subcutaneous injection, as you were taught. Avoid getting the drug directly into the vein. Enter the solution by gently pressing the plunger. Use as much time as you need to enter the entire volume of the solution. Immediately after the injection, remove the needle and wipe the skin at the injection site with a swab with alcohol.

2. Disposal of used accessories: Immediately after injection, place the used syringe in a container for storing sharp objects. All unused solution must be destroyed.

For the syringe pen:

Use the syringe pen only for yourself, do not let anyone else use it.

Use Ovitrel® as directed showed a doctor or nurse.

The illustration below shows the appearance of the syringe pen, indicating its individual elements:

1. button for setting the dose

2. indicator board

3. the piston

4. tank compartment

5. threaded tip

6. pen-syringe cap

7. removable needle

8. inner needle cap

9. outer needle cap

10. protective sticker

1. Preparation of a syringe-pen for injection

1.1 Remove the cap from the syringe pen

1.2 Put on the needle

- Take the needle - use only disposable needles supplied together with the pre- completed syringe-pen Ovitrel®.

- Make sure that the protective label on the outer cap of the needle is not damaged or weakened.

ATTENTION:

If the protective label is damaged or loose, do not use this needle. Take another. Dispose of the unused needle with the outer cap on it. Instructions for disposing of unnecessary needles should be obtained from your doctor or nurse.

- Remove the protective sticker.

- Firmly hold the outer needle cap.

- Insert the tip of the syringe-handle with the thread into the outer cap of the needle and screw the outer cap until it firmly fixes.

1.3 Remove large air bubbles:

- Inspect the tank compartment carefully.

- If you did not find a large air bubble, then the pen-pen is ready to use. In this case go to step 2 "Set the dose at 250".

An air bubble is considered large if it completely fills the tip of the cartridge compartment when the needle is held up by the needle (see illustration). If you see a large air bubble inside the reservoir compartment, it must be removed. In the syringe handle, there may be several small air bubbles adhering to the inner wall of the compartment with the reservoir. Do not pay attention to small bubbles, they do not have to be removed.

To remove a large air bubble

1. Carefully rotate the button to set the dose in a clockwise direction until the dot (-) appears on the dose indicator panel. If you skipped this position, simply turn the button back to the point (-).

2. Then remove the inner needle cap and hold the needle pen up with the needle.

3. Slightly tap the reservoir compartment with your finger so that all air bubbles float up to the needle.Continuing to hold the needle pen up with the needle and gently pushing the button to set the dose, push the plunger out until the air bubble is released.

4. At the tip of the needle, a drop of solution should appear; this means that your syringe pen is ready to be injected.

5. If the solution does not come through at the tip of the needle, repeat the manipulations described above again (the maximum number of attempts is 2), starting with step 1 ("To remove a large air bubble" item).

2. Setting the dose at 250

- Carefully turn the button to set the dose clockwise until the number "250" appears on the display of the dose indicator instead of a straight line.

- Turning the button to set the dose should not be pressed on it or, conversely, delayed.

- On the display of the dose indicator should appear the number "250", as shown in the figure below.

3. Dosing Introduction

1. Select a site for injection as indicated by your doctor or nurse.

2. Disinfect the injection site by wiping it with a swab dipped in alcohol.

3. Make sure again that the number is "250" on the scoreboard. If there is no number on the scoreboard, you need to set the correct dose (see section 2 "Setting the dose at 250").

4. Carefully remove the inner cap and discard it (if this has not already been done by following the instructions in 1.3 "Remove large air bubbles").

Enter the dose as directed by your doctor or nurse

- First, slowly insert the needle under the skin, then press the button to set the dose until it stops, as shown in the figure below.

- The number with the dosage indicated on the display of the dose indicator will return to the "O" position. This means that the whole dose has been introduced.

- Leave the needle under the skin with the button pressed to set the dose for at least 10 seconds.

- After 10 seconds, remove the needle by holding down the button to set the dose.

4. After the injection

4.1 Make sure that the number of "0" appears on the display of the dose indicator.

- This means that the dose has been introduced completely. Do not attempt to inject a second time.

- If the number "0" does not appear on the scoreboard, contact your doctor or nurse.

4.2. Removing the needle

- Hold the syringe handle firmly behind the reservoir compartment.

- Carefully place the outer cap on the needle.

- Then squeeze the outer cap and unscrew the needle.