Oxytocin - instructions for use, dose, side effects, contraindications

Oxytocin - synthetic peptide hormone analogue posterior lobe of the pituitary gland - stimulates contraction of smooth muscles uterus (special pregnant) and myoepithelial cells mammary gland.

Oxytocin renders weak antanddiuretic effect in therapeutic doses does not significantly affect blood pressure.

The effect comes 1-2 min with n / k and in / m introduction, lasts 20-30 minutes; with iv introduction - in 0.5-1 minutes.

Pharmacokinetics:

T _1/2 - 1-6 mines (decreases in late terms pregnancy and lactation). Communication with plasma proteins - low (30%). Metabolised in the liver and kidneys. During pregnancy in plasma, target organs, placenta, the content of oxytocinase, inactivating the endogenous and exogenous oxycotin, increases. Excretion, mainly by the kidneys in unchanged form.

Indications:

To excite and stimulation of ancestral activities; for prevention and treatment of hypotonic uterine bleeding in early postnatal period and to accelerate postpartum involution of the uterus; to strengthen uterine contractility in cesarean section (after removing the afterburn).

Contraindications:

Increased individual sensitivity to a preparation, an arterial hypertensia, renal insufficiency, predisposition to rupture uterus, mismatch in size pelvis of the mother and fetus (narrow pelvis anatomical and clinical), transverse or oblique fetal position, premature birth, menacing rupture of the uterus, scarring after a cesarean section or other operations on the uterus, excessive stretching of the uterus, uterus after multiple births, uterine septicemia, invasive carcinoma of the cervix, hypertension of the uterus (arisen not during childbirth), compression of the fetus, suspicion of premature detachment placenta, intrauterine fetal hypoxia, placenta previa.

Dosing and Administration:

Oxytocin is administered intravenously, intramuscularly, into the wall or vaginal part of the cervix.

For excitation of childbirth intramuscularly inject 0.5-2.0 ME oxytocin; if necessary, repeat the injection every 30-60 minutes.

For intravenous drip injection, dilute 1 ml of oxytocin (5 ME) in 500 ml of a 5% solution of dextrose. Introduction begins with 5-8 drops per minute, followed by an increase in speed, depending on the nature of labor, but not more than 40 drops per minute.During the infusion, constant monitoring of uterine activity and fetal heart rate is necessary.

For the prevention of hypotonic uterine bleeding oxytocin is administered intramuscularly 3 - 5 IU 2-3 times a day daily for 2-3 days, and for the treatment of hypotonic uterine bleeding 5-8 ME are administered 2-3 times a day for 3 days.

In the operation of cesarean section (after removal of the afterbirth) oxytocin Enter into the wall of the uterus in a dose of 3-5 ME.

Side effects:

Possible arrhythmia and bradycardia (in the mother and fetus), decrease or increase arterial pressure, shock, subarachnoidal bleeding, nausea, vomiting, neonatal jaundice, decreased fibrinogen content in the fetus, allergic reactions, Bronchospasm, water retention, excessively active generic activity, which can cause acute fetal hypoxia, premature detachment normally located placenta, ruptured uterus.

When these symptoms appear complications should be stopped immediately introductionpproducta.

Overdose:

Symptoms: hyperstimulation of the uterus, which can lead to hypertonia and tetanic contractions of the uterus, which in turn can lead to rupture of the uterus, postpartum hemorrhage, various changes from cardiac activity fetus, hypoxia and fetal death: compression of the fetus, fetal asphyxia, fetal bradycardia, utero-placental hypoperfusion, hypercapnia, birth injury to the fetus, water intoxication, convulsions.

Treatment: Immediately stop the introduction oxytocin, reduce the administration to force diuresis, to introduce symptomatic drugs and hypertensive Saline solutions (to normalize the electrolyte balance), barbiturates (with caution). Behind the patient careful monitoring is necessary.

Interaction:

Carefully apply Oxytocin in combination with sympathomimetics (potentiate pressor action of sympathomimetics).

In combination with MAO inhibitors, the risk of increasing blood pressure increases.

Halothane and cyclopropane increase the risk of developing arterial hypotension.

Special instructions:

It is used only under medical supervision in conditions hospital under control cut backactivities uterus, fetal conditions, blood pressure and general status of women.

Form release / dosage:RAsterol for intravenous and intramuscular administration, 5 IU / ml.

Packaging:1 ml per ampoule of neutral glass.

5 ampoules per contour cell packaging made of polyvinylchloride (PVC) film.

1 or 2 contour packs with instructions for use and a scapegrator ampoule in a pack of cardboard.

5 or 10 ampoules together with the instruction for use and the ampoule scarifier are placed in a pack of cardboard with a corrugated liner.

When using ampoules with a dot or a ring of fracture, the ampoule scaper is not inserted.

Packing for hospitals

For 50 or 100 contour cell packs with ampoules together with an equal number of instructions for use are placed in a box of corrugated cardboard.

Storage conditions:

In the dark place at temperature from 4 to 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Not use after the expiration date indicated on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N003368 / 01

Date of registration:24.06.2009 / 04.04.2017

Expiration Date:Unlimited

The owner of the registration certificate:ELLARA, LTD. ELLARA, LTD. Russia

Manufacturer: & nbsp

MC ELLARA, LLC Russia

Information update date: & nbsp24.05.2017

Illustrated instructions

Instructions

Oxytocin (Oxytocinum)