Oxodoline (Oxodolinum)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceChlorthalidoneChlorthalidone
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  • Oxodoline
    pills inwards 
    ORGANICS, JSC     Russia
    • Dosage form: & nbsppills
    Composition:
    Active substance: Oxodoline (chlorthalidone) - 50 mg.
    Excipients: lactose, potato starch, povidone low molecular weight, calcium stearate.
    Description:Tablets are white or white with a slightly yellowish tint of color.
    Pharmacotherapeutic group:Diuretics
    ATX: & nbsp

    C.03.B.A.04   Chlorthalidone

    Pharmacodynamics:

    Diuretic agent. Suppresses active reabsorption of sodium ions (Na+), mainly in the peripheral renal tubules (the cortical segment of the Henle loop), increasing the excretion of chloride ions (Cl-) and water. Excretion of potassium ions (K+) and magnesium ions (Mg2+) through the kidneys increases, while excretion of calcium ions (Ca2+) is reduced. Causes a slight decrease in blood pressure (BP), the severity of the hypotensive effect gradually increases and manifests itself in full 2-4 weeks after the initiation of therapy.

    At the beginning of therapy, a significant decrease in the volume of extracellular fluid, the volume of circulating blood and the minute volume of blood, but after several weeks of use, these indicators return to a level close to the initial.

    Like thiazide diuretics, it causes a decrease in polyuria in patients with renal diabetes insipidus.

    The onset of action is 2-4 hours after ingestion, the maximum effect is after 12 hours, the duration of the action is 2-3 days.

    Pharmacokinetics:
    Absorption - 50% for 2.6 hours. Bioavailability - 64%. After ingestion of 50 mg and 100 mg, the maximum concentration is achieved after 12 hours and is 9.4 and 16.5 mmol / l, respectively. Connection with plasma proteins - 76%.
    The half-life is 40-50 hours. It is excreted by the kidneys unchanged. Penetrates into breast milk. With chronic kidney failure can cumulate.
    Indications:Chronic heart failure of II degree, arterial hypertension, cirrhosis with portal hypertension, nephrosis, nephritis, renal form of diabetes insipidus, dysproteinemic edema, obesity.
    Contraindications:Increased sensitivity (including sulfonamide derivatives), hypokalemia, severe progressive forms of nephrosis and nephritis with decreased glomerular filtration rate, acute renal failure with anuria, hepatic coma, acute hepatitis, diabetes mellitus (severe forms), gout, water disturbances Electrolyte balance, lactation period, age under 18 years (efficacy and safety not established).
    Carefully:Renal and / or liver failure, allergic reactions, bronchial asthma, systemic lupus erythematosus, the elderly will be rewarded.
    Dosing and Administration:
    Inside (usually in the morning before breakfast). Doses are selected individually depending on the severity and nature of the disease and the effect obtained. With prolonged therapy, it is recommended to prescribe the lowest effective dose, sufficient to maintain the optimal effect, especially in elderly patients.
    With a mild degree of arterial hypertension - 50 mg once a day 3 times a week. With edematous syndrome, the initial dose is 100 mg every other day (doses above 100 mg usually do not cause an increase in the diuretic effect), then it is necessary to switch to a maintenance dose of 100-120 mg per day 3 times a week.
    In the renal form of diabetes insipidus: the initial dose is 100 mg 2 times a day, the maintenance dose is 50 mg per day.
    Side effects:From the digestive system: nausea, vomiting, gastro spasm, constipation or diarrhea, intrahepatic cholestasis, jaundice, pancreatitis.

    From the nervous system: dizziness, paresthesia, asthenia (unusual fatigue or weakness), disorientation, apathy.

    From the sense organs: xanthopia, visual impairment.

    From the hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis, eosinophilia, aplastic anemia.

    From the cardiovascular system: Orthostatic hypotension (may increase under the influence of ethanol, anesthetics and sedatives, arrhythmia (due to hypokalemia).

    Laboratory indicators: hypokalemia, hyponatremia (including accompanied by neurological symptoms - nausea), hypomagnesemia, hypochloraemic alkalosis, hypercalcemia, hyperuricemia (gout), hyperglycemia, glucosuria, hyperlipidemia. Allergic reactions: urticaria, photosensitivity.

    Other: muscle spasm, decreased potency.

    Overdose:
    Symptoms: dizziness, nausea, drowsiness, hypovolemia, excessive decrease in blood pressure, arrhythmia, convulsions.
    Treatment: rinse the stomach, prescribe inside the activated charcoal, symptomatic therapy (including intravenous injection of saline solutions to restore the electrolyte balance of blood).
    Interaction:

    Increases the concentration of lithium ions (Li+) in the blood (in the case when Li+ causes polyuria can have antidiuretic effect) and thus increases the risk of drug intoxication Li+.

    Strengthens the effect of curare-like muscle relaxants and hypotensive drugs (including guanethidine, methyldopy, beta-adrenoblockers, vasodilators, blockers of "slow" calcium channels, monoamine oxidase inhibitors).

    Against the background of taking cardiac glycosides, it can aggravate cardiac rhythm disturbances that occur as a result of digital intoxication.

    The hypokalemic effect of the drug is enhanced with the concomitant administration of glucocorticosteroid agents, amphotericin and carbenoxolone.

    Nonsteroidal anti-inflammatory drugs weaken the diuretic and hypotensive effect of the drug.

    It may be necessary to correct (increase or decrease) the dose of insulin and increase the dose of oral hypoglycemic agents.

    Special instructions:
    During the treatment period, it is necessary to periodically determine blood electrolytes, especially in patients taking digitalis preparations.
    It is not recommended to prescribe to patients a very strict salt-free diet.At the appearance of signs of hypokalemia (myasthenia gravis, heart rhythm disturbance) or if there is an additional possibility of potassium loss in patients (vomiting, diarrhea, malnutrition, cirrhosis, hyperaldosteronism, adrenocorticotropic hormone therapy, GCS), substitution therapy with potassium preparations is indicated.
    In patients with hyperlipidemia, the serum lipids should be monitored continuously (in the event of an increase in their concentration, therapy should be discontinued). Against the background of taking thiazide diuretics there was an exacerbation of systemic lupus erythematosus. Although similar phenomena with the use of chlorthalidone is not revealed, when it is prescribed to patients with systemic lupus erythematosus, care should be taken.
    Form release / dosage:
    Tablets of 50 mg.
    Packaging:5 contour cell packs of 10 tablets or 50 tablets in a can of light-protective glass or in a plastic jar along with instructions for use in a cardboard bundle.
    Storage conditions:
    List B.
    In a dry, the dark place at a temperature of no higher than 30 ° C. Keep out of the reach of children.
    Shelf life:5 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-003344/08
    Date of registration:30.04.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp25.05.2017
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