Pantogam asset (Pantogam activ)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceD, L-Hopantenic acidD, L-Hopantenic acid
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  • Pantogam asset
    capsules inwards 
    PIK-PHARMA, LLC     Russia
    • Dosage form: & nbspcapsules
    Composition:

    1 capsule contains:

    active substance: rac-Hopantenic acid (D,L-Hopantenic acid & amp; 300 mg;

    Excipients: cellulose microcrystalline 20.97 mg, magnesium stearate 1.53 mg; Hard gelatin capsules No. 0 (composition of capsules: titanium dioxide 2%, gelatin up to 100%).

    Description:

    Hard gelatin capsules № 0 of white color. The contents of capsules are white or white powder with a yellowish tinge.

    Pharmacotherapeutic group:nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    Pharmacodynamics:

    The action of Pantogam is related to the presence of gamma-aminobutyric acid (GABA) in its structure, which directly affects GABAB- receptor-channel complex. Pantogam the asset is a racemic mixture of equal amounts Rform of gopantenic acid and its Sisomer. The presence of the isomer improves the transport and interaction of the drug with the GABA receptor. Pantogam asset has a more pronounced nootropic and anticonvulsant action than preparations of first-generation hapantenic acid.

    Pantogam, an active increases the resistance of the brain to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons,combines a moderate sedative effect with a mild stimulating effect. Has anti-asthenic and light anti-anxiety effect. Reduces motor excitability, organizes behavior. Activates mental activity and performance. Causes inhibition of pathologically increased vesical reflex and tone detrusor.

    Pharmacokinetics:

    Quickly absorbed from the gastrointestinal tract. Penetrates through the blood-brain barrier. It is not metabolized and is excreted unchanged for 48 hours: about 70% of the dose taken with urine, about 30% with feces.

    Indications:

    - Cognitive impairment in organic brain lesions (including the effects of neuroinfections and craniocerebral trauma) and neurotic disorders;

    - cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels;

    - extrapyramidal hyperkinesis (myoclonus-epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment of extrapyramidal syndrome caused by the administration of neuroleptics;

    - with epilepsy in conjunction with anticonvulsants;

    - psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization;

    - neurogenic disorders of urination (pollakiuria, imperative urges, mandatory urinary incontinence, enuresis);

    - with schizophrenia in complex therapy.

    Contraindications:- Hypersensitivity;
    - acute severe kidney disease;
    - The age of the patient is under 18 years of age (there are no clinical studies on the use of the drug at an earlier age).
    Pregnancy and lactation:

    Contraindicated use of the drug during pregnancy and during breastfeeding.

    Dosing and Administration:

    Inside, 15-20 minutes after eating 1-3 capsules (0.3-0.9 g) 2-3 times a day, preferably in the morning and afternoon. The maximum daily dose of 8 capsules (2.4 g). The course of treatment is 1-4 months, sometimes up to 6-12 months. After 3-6 months, a repeat course of treatment is possible.

    Side effects:

    In rare cases, allergic reactions are possible (rhinitis, conjunctivitis, skin rashes). In this case, cancel the drug.

    Very rarely there are undesirable reactions from the central nervous system (CNS): sleep disturbance or drowsiness, headache,dizziness, noise in head. In this case, reduce the dose of the drug.

    Overdose:

    Increased symptoms of side effects.

    Treatment: Activated carbon, gastric lavage, symptomatic therapy.

    Interaction:

    Prolongs the effect of barbiturates, enhances the effects of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, neuroleptics.

    The Pantogam effect is intensified when combined with glycine, etidronic acid.

    Potentsiruet action of local anesthetics (procaine).

    Special instructions:

    In the conditions of long-term treatment, simultaneous administration of the drug with other nootropic and CNS-stimulating agents is not recommended.

    Form release / dosage:Capsules, 300 mg.
    Packaging:

    For 10 or 15 capsules in a contour mesh box made of polyvinyl chloride film and aluminum foil printed lacquered.

    2 or 4 contour packs of 15 capsules or 3 or 6 contour packs of 10 capsules together with the instructions for use are placed in a pack of cardboard.

    Storage conditions:

    In a dry, protected from light place, at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 of the year.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-003873/08
    Date of registration:21.05.2008
    The owner of the registration certificate:PIK-PHARMA, LLC PIK-PHARMA, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspPIK-PHARMA LLC PIK-PHARMA LLC Russia
    Information update date: & nbsp24.12.2015
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