Hypersensitivity to the components of the drug, hypertension (high blood pressure), severe atherosclerosis, chronic heart failure, organic heart disease, angina, increased excitability, sleep disturbances, increased blood clotting, severe liver disease, severe jade forms, diarrhea, malignant neoplasms, deficiency of lactase, lactose intolerance, glucose-galactose malabsorption, pregnancy, the period of breastfeeding, age to 18 years.