Paract can be used both in the form of monotherapy, and in combination with other antitumor drugs. When choosing a dose and treatment in each individual case, you should use special literature.
The drug is administered intravenously in the following dose regimens:
- 300-400 mg / m2 intravenously drip for 15-60 minutes or as a 24-hour infusion;
- 100 mg / m2 intravenously drip for 15-60 minutes daily for 5 days.
Introduction A parake is repeated at intervals of not less than 4 weeks with platelet counts of at least 100,000 cells / μl of blood and neutrophils of at least 2000 cells / μL of blood at the time of the next administration.
The introduction of liquid before or after the application of the Paracta, as well as the achievement of forced diuresis is not required.
Depending on the condition of the bone marrow or the function of the kidneys, the therapeutic dose of Paract can be corrected as follows:
- with a decrease in the number of platelets to 50,000 / mm3 and / or neutrophils to 500 / μl, no previous dose adjustment is required for previous carboplatin therapy;
- with the observed minimum platelet counts of less than 50,000 / μL and / or neutrophils less than 500 / μL in the previous course of carboplatin therapy, consideration should be given to reducing the next dose by 25% in both monotherapy and combined treatment regimens;
- if the renal function is impaired (creatinine clearance less than 60 ml / min), the risk of toxic effects of carboplatin increases, and therefore recommended doses of carboplatin are at creatinine clearance of 41-59 ml / min - 250 mg / m2, with the clearance of creatinine 16-40 ml / min - 200 mg / m2;
- patients with risk factors, such as, for example, previous courses of myelosuppressive therapy, age over 65 years, low functional status (ECOG-Zubrod 2-4 or the Karnovsky index below 80%), it is recommended to reduce the initial dose of carboplatin by 20-25%.
Determination of the dose by the formula
The initial dose of the preparation in milligrams can be determined by the Calvert formula, which describes the dependence of the glomerular filtration rate (GFR in ml / min) and the desired drug concentration on timeAUC in mg / ml x min):
Total Dose (mg) = AUC x (GF + 25)
| Desired value AUC * | Planned chemotherapy with the drug Paract | Status of the patient with regard to treatment |
| 5-7 mg / ml.min | Monotherapy | Previously untreated |
| 4-6 mg / ml. Min | Monotherapy | Previously treated |
| 4-6 mg / ml. Min | In combination with cyclophosphamide | Previously untreated |
Rules for the preparation of a solution for infusions
Before administration, the drug is diluted to a concentration of 0.5 mg / ml with a 5% dextrose solution or 0.9% sodium chloride solution.
Dilute drug solutions are stable for 8 hours at 25 ° C and for 24 hours when stored in a refrigerator at 4 ° C.