Paracetamol + Rimantadine + Ascorbic acid + Loratadine + Rutoside + Calcium carbonate (Paracetamolum + Rimantadinum + Acidum ascorbinicum + Loratadinum + Rutosidum + Calcii carbonas)

Clinical and pharmacological group: & nbsp

Non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Included in the formulation
АТХ:

R.05.X   Other combined drugs used for catarrhal diseases

Pharmacodynamics:

Combined drug.

Paracetamol

Has antipyretic, analgesic and anti-inflammatory effect. Inhibits cyclooxygenase, mainly in the central nervous system, affects the centers of pain and thermoregulation. It does not have a negative effect on water-salt metabolism and mucous membranes of the gastrointestinal tract, and therefore has little effect on the synthesis of prostaglandins in peripheral tissues.

Rimantadine

Has an antiviral effect against influenza A virus. It increases the pH of endosomes that have the vacuole membrane that surround the viruses after they enter the cell, blocking the fusion of the viral envelope with the endosome membrane, preventing the transfer of the genetic material of the virus to the cytoplasm of the cell. Inhibits the release of viral particles from the cell, interrupting the transcription of the viral genome.

Ascorbic acid

Regulates the transport of hydrogen ions in oxidation-reduction reactions, including in the process at any stage of the Krebs cycle. Participates in the regulation of carbohydrate metabolism. Provides absorption of iron in the intestine, transferring it from trivalent into a divalent form, facilitating its incorporation into heme. Participates in the formation of tetrahydrofolic acid, the synthesis of steroid hormones, norepinephrine and adrenaline, collagen, prothrombin, glycogen. Inactivates hyaluronidase, activating the regeneration of tissues and normalizing the permeability of capillaries. Disinfects toxins and has an antioxidant effect, catching free radicals. He takes an active part in the regulation of immune processes: enhances the formation of antibodies, phagocytic activity and the synthesis of interferon. It inhibits the release of histamine and strengthens its degeneration, suppresses the release of mediators of inflammation and allergic reactions.

Loratadin

Selective blocker H1-gistaminovyh receptors. Reduces the swelling of the nasal mucosa, improving nasal breathing, eliminates the symptoms of allergic rhinitis: itching in the nasal cavity, sneezing, rhinorrhea.

Rutozid

Rutozid prolongs the action of ascorbic acid, neutralizing vitamin C oxidase. It has the properties of competitive antagonism with catechol-ortho-methyltransferase, enhancing the action of noradrenaline and adrenaline on the level of the microvascular bed. Reduces the permeability of the walls of the vessels and the filtration of water in the capillaries, inhibits the aggregation of erythrocytes.

Calcium carbonate

Calcium prevents the development of fragility and increased permeability of blood vessels, stimulates the formation of bone tissue, participates in blood clotting processes, stabilizes cardiac activity, carries out nerve impulses, and has a membrane-stabilizing effect.

Pharmacokinetics:

Not studied.

Indications:

It is used to treat influenza A.

X.J10-J18.J10   Influenza caused by an identified influenza virus

Contraindications:

Bleeding in the gastrointestinal tract, phenylketonuria, deficiency of glucose-6-phosphate dehydrogenase, portal hypertension, anemia, leukopenia, thrombocytopenia, individual intolerance.

Carefully:

Hepatic and renal failure, urolithiasis, epilepsy, Gilbert's syndrome, viral hepatitis, old age, alcoholism.

Pregnancy and lactation:

Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

Dosing and Administration:

Inside after eating, washing down with water, 2 capsules 2-3 times / day for 3-5 days.

The highest daily dose: 6 capsules.

The highest single dose: 2 capsules.

Side effects:

Central and peripheral nervous system: dizziness, headache, hyperkinesia, tremor.

The system of hematopoiesis: anemia, agranulocytosis

Digestive system: dyspepsia, anorexia, diarrhea, flatulence.

Allergic reactions.

Overdose:

Symtomas: diarrhea, anorexia - with acute overdose (develops 6-14 hours after exceeding the dose), with chronic (develops 2-4 days after exceeding the dose) - hypocoagulation, DIC syndrome, cerebral edema, rarely - fulminant renal failure due to tubular necrosis .

Necrosis of liver cells, due to the formation of a toxic metabolite of acetaminophen - N-acetyl-p-benzoquinonimine.

Treatment: application of donators SH-groups, precursors of the synthesis of glutathione-methionine and N-acetylcysteine ​​for 12 hours after an overdose.

Interaction:

Strengthens the effect of indirect coagulants and toxicity of chloramphenicol.

The intake of ethanol in the treatment of the drug leads to the development of acute pancreatitis.

Simultaneous use with stimulators of microsomal oxidation in the liver - barbiturates, rifampicin, ethanol, phenylbutazone, phenothionine, increases the toxicity of paracetamol.

Reduces the risk of hepatotoxic effects of microsomal oxidation inhibitors (cimetidine).

Special instructions:

Monitoring of glucose and uric acid in the plasma, the composition of peripheral blood, the functional state of the liver.

It is not recommended to take the drug for more than 5 days. During treatment it is forbidden to drink alcohol.

During treatment, care must be taken when driving vehicles and working with moving machinery.

Instructions
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