Additional dilution is allowed 0.9% solution of sodium chloride or 5% solution of dextrose, in addition to 1/10 of the original volume.The diluted solution should be used within an hour after preparation, including the infusion time.
For infusion, use a needle with a diameter of 0.8 mm, which is injected into the vial in a place marked on the rubber stopper, holding the bottle strictly vertically.
As with other solutions for infusions supplied in glass containers, in order to avoid embolism with air bubbles, respect the special
caution, especially at the end of the infusion, regardless of the type of vein the drug is injected into.
Unintentional surplus recommended doses can lead to a serious impairment of liver function, including fatal outcome. When determining the dose, individual factors risk hepatotoxicity present in the patient: hepatic insufficiency, chronic alcoholism, chronic eating disorders, dehydration.
Doses are calculated based on the patient's body weight.
| Weight bodies the patient | Dose paracetamol for one application of (solution of 10 mg / ml) | Minimalth interval between receptions | Maximum daily dose* |
| > 50 kg | 1 g, i.e. 1 vial (100 ml) up to 4 times a day | 4 hours | Not more than 4 g |
| > 33 kg - <50 kg | 15 mg / kg, i.e. 1.5 ml / kg up to 4 times a day | 4 hours | <60 mg / kg, but not more than 3 g |
| > 10 kg - <33 kg | 15 mg / kg, i.e. 1.5 ml / kg up to 4 times a day | 4 hours | <60 mg / kg, but not more than 2 g |
| <10 kg ** | 7.5 mg / kg, i.e. 0.75 ml / kg up to 4 times a day | 4 hours | <30 mg / kg, the maximum daily dose is not more than 30 mg / kg |
* The maximum daily dose, taking into account the intake of all drugs containing
paracetamol or propacetamol.
** Safety and efficacy of the drug for premature infants are not established.
When the drug is administered to children and adolescents, the vial with the drug can not be suspended as an infusion vessel due to the small volume of the drug administered.
To avoid mistakes in the calculation of doses for children with a body weight of less than 10 kg, it is recommended to specify the volume for a single injection in milliliters (ml), while in this group of patients introduced amount medicinal product Perfalgan® solution for infusions of 10 mg / ml should not exceed 7.5 ml per infusion.
Patients with a lower body weight require the introduction of smaller volumes of the drug.
In order to measure the dose of the drug with taking into account the body weight of the child and the volume, use syringes volume of 5 ml or 10 ml.
The volume required for administration to the patient should be removed from the bottle and diluted in 0.9% solution of sodium chloride or in a 5% solution of dextrose in ratio of one to ten (one volume preparation in nine volumes of the solution for and enter into the patient for 15 minutes. In severe violations of kidney function (creatinine clearance <30 mL / min) interval between drug administration should not less than 6 hours.
With chronic liver disease or compensated liver disease in active stage in adults, in particular with hepatic insufficiency, and patients with chronic alcoholism, eating disorders or dehydration, the daily dose should not exceed 3 g. Dose adjustments for elderly patients are not it takes.