Included in the formulation
АТХ:B.05.D Solutions for peritoneal dialysis
Pharmacodynamics:A 7.5% solution based on a starch derivative (polymer) isoosmolar in blood plasma, acts as an osmotic agent, allows ultrafiltration for 12 hours under conditions of continuous outpatient peritoneal dialysis without changing the amount of insulin and the concentration of glucose in the blood.
Pharmacokinetics:Not described.
Indications:Used to replace dextrose for the procedure of permanent outpatient or automated peritoneal dialysis in chronic renal failure, complicated by violations of the filtration function of the kidneys.
XXI.Z40-Z54.Z51.4 Preparatory procedures for subsequent treatment, not elsewhere classified
Contraindications:Maltose intolerance, isomaltoses, individual intolerance of icodextrin and other polymers based on starch, children under 18 years.
Carefully:Respiratory failure, hypokalemia, digestive disorders.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Intraperitoneally 1 time per day in the longest period between dialysis procedures. The time for removing the used solution and introducing the new one takes 10-20 minutes. The residence time of the solution in the abdominal cavity with constant outpatient peritoneal dialysis is 6-12 hours, with the automated - 14-16 hours.
The highest single dose: 2 liters.
The highest daily dose: 2 liters.
Side effects:Abdominal pain, electrolyte disorders, muscle cramps, peritonitis, decreased appetite, constipation, swelling, visual impairment, dyspnea, allergic reactions. Side effects are caused both by the solution itself and by the procedure.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Not described.
Special instructions:Application of icodextrin in patients with diabetes requires correcting the dose of insulin.