Central and peripheral nervous system: dizziness, headache, insomnia, fainting, hemorrhagic stroke, peripheral neuropathy, drowsiness, migraine, depression, cognitive disorders, confusion, brain edema, convulsions.
Respiratory system: shortness of breath, cough, rarely - pneumonitis, respiratory failure, dysphonia, pulmonary edema.
The system of hematopoiesis: anemia, neutropenia, thrombocytopenia, leukopenia, febrile neutropenia, rarely - lymphopenia, coagulopathy.
The cardiovascular system: lowering of arterial pressure, ventricular dysfunction, myocardial infarction, supraventricular arrhythmia, thrombosis, rarely - stenocardia, myocardial ischemia, cardiomyopathy, atrial fibrillation, hypovolemic shock, pulmonary embolism, vasculitis, bleeding.
Digestive system: stomatitis / mucositis, abdominal pain, vomiting, diarrhea, constipation, nausea, gastroesophageal reflux disease, esophagitis, colitis, intestinal obstruction, evacuation of gastric contents, rarely - dysphagia, gastrointestinal bleeding, gastritis.
Musculoskeletal system: myalgia, arthralgia, muscle weakness, rarely - muscle spasms, trismus.
Dermatological reactions: alopecia, skin rashes, erythrodysesthesia syndrome fingers and toes, hyperpigmentation of the skin, itching, skin peeling, nail damage, rarely - erythema multiforme.
Sense organs: conjunctivitis, blurred vision, lacrimation, tinnitus.
Reproductive system: increase of mammary glands, gynecomastia, pain in the nipples, swelling of the scrotum, decreased potency.
Allergic reactions.