Infectious and parasitic diseases: often - septic shock, sepsis, cellulitis, urinary tract infections of all severity, flu, cystitis, upper respiratory tract infection, herpes zoster, candidiasis; infrequently - cellulite, cystitis.
On the part of the hematopoiesis system: very often - neutropenia of all degrees of severity, including neutropenia with clinical manifestations, anemia of all severity, leukopenia of all severity, thrombocytopenia; often - febrile neutropenia, thrombocytopenia.
From the immune system: often - hypersensitivity reactions, including severe reactions, such as generalized rash / erythema, lowering blood pressure and bronchospasm.
From the side of metabolism: very often - anorexia; often - dehydration of all degrees of severity, hyperglycemia, hypokalemia, weight loss; infrequently - anorexia, hyperglycemia, hypokalemia.
From the nervous system: very often - dysgeusia (perversion of taste); often-peripheral neuropathy: peripheral sensory neuropathy (paresthesia, dysesthesia, hypoesthesia) and peripheral motor neuropathy; dizziness, headache, lethargy, sciatica, restlessness, confusion; infrequently peripheral neuropathy, peripheral sensory neuropathy, lethargy, sciatica.
From the side of the organ of vision: often - conjunctivitis, increased tearing.
From the side of the organ of hearing and balance: often - ringing in the ears, vertigo (feeling of deviation or twisting of one's own body or surrounding objects).
From the cardiovascular system: often - atrial fibrillation (atrial fibrillation), tachycardia, decreased blood pressure, deep vein thrombosis of all severities, increased blood pressure, orthostatic hypotension, flushing to the skin with a feeling of heat, hyperthermia; infrequently - atrial fibrillation (atrial fibrillation), lowering blood pressure, increasing blood pressure, orthostatic hypotension.
From the respiratory system: very often - shortness of breath, cough; often - shortness of breath, pain in the mouth and pharyngeal cavity, pneumonia of all degrees of severity.
From the digestive system: very often - diarrhea, nausea, vomiting, constipation, abdominal pain; often - an increase in activity of aspartate aminotransferase, diarrhea, nausea, vomiting, constipation, abdominal pain, dyspepsia, epigastric pain, hemorrhoids, gastroesophageal reflux disease,bleeding from the rectum, dry mouth, bloating; infrequently - an increase in serum bilirubin concentration, increased activity of alanine aminotransferase, rectal bleeding, dry mouth, bloating.
From the skin and subcutaneous tissues: very often - alopecia; often - dry skin, erythema.
From the musculoskeletal system: very often - pain in the spine, arthralgia; often - pain in the spine, arthralgia, pain in the extremities of all degrees of severity, muscle spasms, myalgia, musculoskeletal pain in the thorax, pain along the lateral surfaces of the trunk; infrequently - myalgia, musculoskeletal pain in the chest area, pain along the lateral surfaces of the trunk.
From the urinary system: very often - hematuria; often acute renal failure of all degrees of severity, renal failure of all degrees of severity, dysuria, renal colic, hematuria, pollakiuria, hydronephrosis, urinary retention, urinary incontinence, obstruction of ureters of all severity; infrequently - renal colic, pollakiuria, hydronephrosis, urinary retention.
On the part of the genitals: often - pelvic pain; infrequently - pain in the pelvic area.
Common violations: very often - weakness, asthenia, pyrexia; often - weakness; asthenia, pyrexia, peripheral edema, inflammation of the mucous membranes, pain in the chest, swelling, chills, malaise; infrequent - peripheral edema, inflammation of the mucous membranes, pain in the chest, swelling.