Calcium carbonate (Calcii carbonas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antacids

Macro and microelements

Included in the formulation
АТХ:

A.12.A.A.04   Calcium carbonate

Pharmacodynamics:

Neutralizes hydrochloric acid and reduces the acidity of gastric juice. Does not affect the production of hydrochloric acid.

Normalizes the electrolyte balance. Inhibits the activity of osteoclasts and inhibits the resorption of bone tissue. Antacid, antiulcer, calcium deficiency compensating action.

Pharmacokinetics:

In a healthy person, about 15% of calcium carbonate is absorbed in the small intestine; the amount of calcium absorbed depends primarily on the effects of parathyroid hormone and vitamin D, dietary characteristics. The absorption of calcium increases with its deficiency and reduced content in the diet Ca2+. In plasma about 45% is in complex with proteins. Elimination by the kidneys (20%) and with feces (80%).

Indications:

Heartburn, discomfort in the epigastric region. Preventive maintenance of an osteoporosis (including at an arthritis, a cancer of a mammary gland, at persons of advanced age). Prophylaxis and treatment of rickets and caries in children.

ICD-10

IV.E50-E64.E55.0   Rickets active

XIII.M80-M85.M81.0   Postmenopausal osteoporosis

XIII.M80-M85.M81.1   Osteoporosis after removal of ovaries

XIII.M80-M85.M81.2   Osteoporosis caused by immobility

XIII.M80-M85.M81.4   Medicinal osteoporosis

XIII.M80-M85.M81.8   Other osteoporosis

XIII.M80-M85.M82.8 *   Osteoporosis in other diseases classified elsewhere

XVIII.R10-R19.R12   Heartburn

Contraindications:

Hypersensitivity, hypercalcemia (hyperparathyroidism, vitamin D overdose, bone metastases), hypercalciuria, nephrolithiasis, chronic renal failure, multiple myeloma, sarcoidosis, phenylketonuria.

Carefully:No data.
Pregnancy and lactation:The use of antacids is considered safe with the exception of long-term administration in large doses.

The category of FDA recommendations is not defined.

Dosing and Administration:

For adults, when used as an antacid, a single dose is 0.5-1 g. For the prevention of osteoporosis, the daily dose is 0.6-1.2 g.

Children for the prevention and treatment of rickets and caries are used in a daily dose of 300-600 mg.

Side effects:

Allergic reactions, dyspeptic phenomena (epigastric pain, flatulence, nausea, constipation / diarrhea), secondary enhancement of gastric secretion, hypercalcemia (at a dose of more than 2 g of calcium per day).

Overdose:

Symptoms: hypercalcemia or milk-alkaline syndrome (at a dose of more than 2 g Ca2+ per day) - headache, weakness, loss of appetite (up to anorexia), nausea, vomiting, constipation, abdominal pain, thirst, polyuria, lethargy, pain in muscles and joints, heart rhythm disturbance, kidney damage.

Treatment: gastric lavage, the appointment of activated charcoal, symptomatic therapy, including the maintenance of vital functions.

Interaction:

With simultaneous ingestion, it is possible to slow the absorption of other drugs.

With simultaneous use with antibiotics of the tetracycline group, the concentration of tetracyclines in the blood plasma decreases and their clinical efficacy decreases.

With simultaneous use with thiazide diuretics, there is a risk of hypercalcemia and metabolic alkalosis.

With simultaneous use with indomethacin, absorption of indomethacin decreases and its irritating effect on the digestive tract decreases.

With simultaneous use, the clinical efficacy of levothyroxine decreases.

With simultaneous use with quinidine - inhibition of renal excretion with increased toxicity of quinidine.

When taken concomitantly with calcitonin, etidronate, gallium nitrate, pamidronate, plikamycin - the latter act as antagonists Calcium carbonate in the treatment of hypercalcemia.

It is not recommended simultaneous administration with mecamylamine, methenamine, sodium polystyrene sulfonate resin (SPSR).

With simultaneous administration with salicylate increases renal excretion and serum concentration decreases

Special instructions:

Long-term intake of calcium carbonate with milk, dairy products can cause diskaltsiemii syndrome (lactic alkaline).

Instructions
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