Included in the formulation
АТХ:A.12.A.A.01 Calcium phosphate
Pharmacodynamics:Combined means.
Calcium
It takes part in the exchange of bone tissue, regulates the process of excitability and contractility in the myocardium, striated and smooth muscle, participates in the processes of excitation of the central and peripheral nervous system, regulation of blood coagulability, vascular wall perceptibility and enzyme activity.
Phosphorus
It is part of the buffer systems and bone tissue.
Pharmacokinetics:After oral administration on an empty stomach Calcium up to 30% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 2 hours. In blood plasma up to 50% is in the active ionized state.
Not exposed to metabolism.
Elimination with feces (80%) and kidneys (20%).
Indications:It is used to fill the deficiency of calcium and phosphorus in case of alimentary failure, pregnancy and lactation. Used for osteoporosis and osteomalacia, hypocalcemia syndrome, with parathyroid gland insufficiency.
XIII.M80-M85.M81.9 Osteoporosis, unspecified
XIII.M80-M85.M81.5 Idiopathic osteoporosis
XIII.M80-M85.M81.4 Medicinal osteoporosis
XIII.M80-M85.M83 Osteomalacia in adults
IV.E20-E35.E21.5 Parathyroid gland disease, unspecified
Contraindications:Hyperparathyroidism, sarcoidosis, myeloma, urolithiasis, individual intolerance, children under 3 years old.
Carefully:Hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category B. It is used in pregnancy and lactation.
Dosing and Administration:1 tablet 2-4 times a day.
The highest daily dose: 600 mg.
The highest single dose: 600 mg.
Side effects:Allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:It interferes with the absorption of phenytoin, fluoride preparations, tetracycline antibiotics, quinolones, etidronate. If it is necessary to use calcium, the interval should not be less than 4 hours.
With simultaneous use with thiazides, the development of hypercalcemia is possible.
Vitamin D increases the bioavailability of calcium.
It enhances the arrhythmogenic effects of cardiac glycosides.
Milk and milk products slow the absorption of calcium.
Special instructions:When taking the drug is not recommended the reception of fatty foods,since calcium combines with fatty acids to form an insoluble calcium soap.