Included in the formulation
АТХ:S.01.X.A.20 Artificial tears and other indifferent drugs
Pharmacodynamics:Interacts on the surface of multilayered corneal epithelium with a thin layer of mucin: non-ionized groups -COOH (carboxylic acid residues) in the polymer form hydrogen bonds with mucin molecules; ionized areas of the carbomer molecule with the help of electrostatic forces keep water around the polymer molecule. Has a very high adhesive ability with respect to the membranes of the corneal epithelium cells and the mucin layer in the lacrimal film. Forms a moisturizing film on the cornea, carrying a protective function. Thickens the mucinous and aqueous layers of tears (see above ability to retain water), increases the overall viscosity and surface tension of the tear film. Prolonged contact with the cornea and a pronounced moisturizing effect determine the effectiveness of the carbomer in the treatment of diseases in which the properties of mucin are violated (acute respiratory infections, infectious, including bacterial, fungal and inflammatory diseases of the eyes), with injuries and erosions of the conjunctiva and cornea,with a decrease in the secretion of tear fluid.
Pharmacokinetics:Does not penetrate into the tissues of the eyeball and does not accumulate in them. Do not undergo systemic absorption from lacrimal ducts.
Indications:Symptomatic treatment of dry keratoconjunctivitis, dry eye syndrome.
VII.H00-H06.H04.1 Other diseases of the lacrimal gland
VII.H10-H13.H10.9 Conjunctivitis, unspecified
Contraindications:Hypersensitivity to the drug.
Carefully:Pregnancy, breast-feeding.
Pregnancy and lactation:The FDA action category is not defined. Adequate and strictly controlled studies in pregnant women have not been conducted, but the potential benefit of the drug for a pregnant woman can justify its use. There is no data on the penetration of the drug into breast milk. Use with caution in lactation.
Dosing and Administration:The drug is applied topically to the cornea of the eye. 1 drop to the affected eye 1-4 times a day and at bedtime.
Side effects:Allergic reactions, transient visual impairment, short-term tingling sensation, eye irritation.
Overdose:Not described. Treatment is symptomatic.
Interaction:Carbomer increases the time of absorption of medicinal products from simultaneously used ophthalmic forms.
Special instructions:It can cause a temporary decrease in visual acuity. Before the beginning of work drivers of vehicles and people whose profession requires visual acuity should wait for its full recovery. During treatment, you should not wear soft contact lenses. Before use, remove hard contact lenses and re-install them no earlier than 15 minutes.
With the simultaneous administration of more than one type of eye drops, they should be used with an interval of at least 15 minutes and carbomer always bury the last.
It is shown that the liquid carbomer-based gel is as effective as the standard one. Gels based on carbomer significantly extend the time of contact of solutions with the cornea.
The drug significantly increases the time of destruction of the tear film.
It is not represented in the United States Pharmacopeia.