Clindamycin (Clindamycinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Lincosamides

Included in the formulation
  • Dalacin®
    cream the vagina. 
    Pharmacy and Upjohn Campani     USA
  • Dalacin®
    gel externally 
    Pharmacy and Upjohn Campani     USA
  • Dalacin®
    suppositories the vagina. 
    Pharmacy and Upjohn Campani     USA
  • Dalacin®
    capsules inwards 
    Pfizer Inc.     USA
  • Dalacin® TS Phosphate
    solution w / m in / in 
    Pfizer IFG Belgium N.V.     Belgium
  • Mirrorin®
    solution externally 
    Yadran Galensky Laboratories a.o.     Croatia
  • Clindamycin
    solution w / m in / in 
    Hemofarm AD     Serbia
  • Clindamycin
    capsules inwards 
    Hemofarm AD     Serbia
  • Clindamycin
    cream the vagina. 
    VERTEKS, AO     Russia
  • Clindathop
    gel externally 
    VALEANT, LLC     Russia
  • Clindacin®
    cream the vagina. 
    AKRIKHIN HFK, JSC     Russia
  • Clindacin®
    suppositories the vagina. 
    FARMAPRIM, LLC     The Republic of Moldova
  • Clindes
    cream the vagina. 
    GEDEON RICHTER, OJSC     Hungary
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    VED

    АТХ:

    J.01.F.F.01   Clindamycin

    Pharmacodynamics:

    Clindamycin belongs to the group of antibiotics of the group of lincosamides, which have a wide spectrum of action. Suppresses protein synthesis in the microbial cell, interacting with the 50S subunits of the prokaryotic ribosomes. It disrupts the synthesis of microbial proteins at the level of the ribosomes, by binding to 50Sthe subunit of bacterial ribosomes, inhibits the process of translocation.It penetrates into cells and creates a high intracellular concentration.

    It is active against Gram-positive pathogenic and conditionally pathogenic microflora, including Staphylococcus epidermidis, Streptococcus spp., Mycoplasma spp., as well as anaerobic microflora, including clostridia.

    Pharmacokinetics:

    After oral administration, up to 90% is absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 6 hours, after intramuscular injection - after 3 hours, with intravenous administration and in children - after 1 hour. The connection with plasma proteins is 90%.

    Metabolism in the liver with the formation of N-demethylated and sulfoxide metabolites, as well as inactive metabolites.

    Half-life is 2-3 hours. Elimination by the kidneys for 7 days. Not removed by dialysis.

    Indications:

    It is used for the treatment of infectious and inflammatory diseases caused by flinders sensitive to clindamycin: with pharyngitis, tonsillitis, sinusitis, otitis, urinary tract infections, osteomyelitis, arthritis, with gynecological diseases, chlamydia and toxoplasmosis.

    ICD-10

    I.A30-A49.A36.9   Diphtheria, unspecified

    I.A30-A49.A38   Scarlet fever

    I.A30-A49.A41.9   Septicemia, unspecified

    I.A30-A49.A49.0   Staphylococcal infection, unspecified

    I.A30-A49.A49.1   Streptococcal infection, unspecified

    I.A30-A49.A49.3   Infection caused by mycoplasma, unspecified

    X.J00-J06.J03.9   Acute tonsillitis, unspecified

    X.J10-J18.J18   Pneumonia without clarification of the pathogen

    X.J40-J47.J47   Bronchoectasia

    XII.L00-L08.L08.0   Pyoderma

    XIV.N70-N77.N70   Salpingitis and oophoritis

    XIV.N70-N77.N71.9   Inflammatory disease of uterus, unspecified

    XIV.N70-N77.N71.0   Acute inflammatory disease of the uterus

    XIV.N70-N77.N72   Inflammatory disease of the cervix

    Contraindications:

    Renal failure, individual intolerance.

    Carefully:Hepatic failure, obstruction of the bile duct, lactation period.
    Pregnancy and lactation:

    Recommendations for FDA - Category B. Contraindicated in the first trimester, in II and III is applied with caution and only in those cases where the potential benefit exceeds the risk to the fetus. Use with caution during lactation.

    Dosing and Administration:

    Use in children

    Newborn: according to vital indications in a dose of 15-20 mg / kg per day in 3-4 doses.

    Older than 1 month: parenterally 20-40 mg / kg per day, the daily dose should be 8-25 mg / kg in 3-4 divided doses.

    In children with a body weight of 10 kg or less, the recommended minimum dose is 37.5 mg of clindamycin palmitate 3 times a day.

    Adults

    For systemic administration: 2400-2700, or 4800 mg per day for 2-4 injections.

    With pelvioperitonitis / adnexitis: intravenous drip of 900 mg with an interval of 8 hours. After the improvement of the condition: inside by 450 mg with an interval of 6 hours for a 10-14-day course of therapy.

    Inside with diseases of moderate and mild severity: 150-400 mg with an interval of 6 hours.

    For the treatment of chlamydia cervicitis: 450 mg orally 3 times a day.

    Outer: 1% gel on dry clean skin at the site of the lesion in the morning and evening.

    Intravaginal: 5 g 2% cream is administered overnight with the help of an applicator.

    The highest daily dose: 4800 mg.

    The highest single dose: 2700 mg.

    Side effects:

    Nausea, vomiting, diarrhea, candidiasis of the mucous membranes of the gastrointestinal tract, vagina.

    Allergic reactions.

    Overdose:

    Acute liver failure.

    Treatment is symptomatic.

    Interaction:

    Increases the half-life of levodopa.

    Incompatible (in solution) with vitamins of group B, with ampicillin, barbiturates, aminophylline, calcium gluconate, magnesium sulfate, erythromycin, phenytoin, euphyllinum.

    Strengthens the effect of muscle relaxants.

    Special instructions:

    Monitoring of kidney and liver function.It is taken only on an empty stomach with a mandatory six-hour interval for five days, with severe infections, the course of treatment can be prolonged up to 10 days.

    Instructions
    Up