When used simultaneously with tricyclic antidepressants (including imipramine, amitriptyline, desipramine, nortriptyline), a decrease in their concentration in the blood plasma is possible.
With simultaneous application with acarbose, acarbose effects can be enhanced.
With simultaneous use with amiodarone decreases the concentration of amiodarone in the blood plasma.
With simultaneous use with sodium valproate, a slight decrease in the absorption of sodium valproate is possible.
With simultaneous use with vancomycin decreases the effectiveness of vancomycin.
With simultaneous use with warfarin, fenprokumonom, dicumarol, ethyl biscumacetate, a decrease in the effectiveness of anticoagulants is possible.
With simultaneous application with hydrocortisone, absorption of hydrocortisone from the digestive tract decreases.
When used simultaneously with hydrochlorothiazide, absorption and diuretic absorptioneffect of hydrochlorothiazide.
When used simultaneously with glipizide, a decrease in glipizide absorption is possible.
At reception with an interval of 1,5 hours colestramine has no significant effect on the concentration of digoxin and digitoxin in blood plasma. Reduction in the concentration of digoxin and digitoxin in the blood plasma is possible with long-term combined use with colestyramine.
With simultaneous use with diclofenac, ibuprofen, absorption of diclofenac and ibuprofen from the digestive tract decreases.
When iron sulfate, phenylbutazone is simultaneously used with iron, it is possible to reduce the absorption of iron sulfate and phenylbutazone.
With simultaneous use with levothyroxine, thyroid hormones, absorption of levothyroxine and thyroid hormones from the digestive tract decreases.
With simultaneous application with loperamide, a decrease in the effectiveness of loperamide is possible.
With simultaneous use with methotrexate, a decrease in the concentration of methotrexate in the blood plasma is possible.
With simultaneous use with metronidazole, a slight decrease in the absorption of metronidazole from the gastrointestinal tract is possible.
With simultaneous application with paracetamol, a decrease in paracetamol absorption is possible.
With simultaneous application with colestyramine, it is possible to increase the excretion of piroxicam, meloxicam, tenoxicam from the body and decrease their effectiveness.
With simultaneous use with pravastatin, fluvastatin, the concentration of pravastatin in blood plasma decreases, Cmax and AUC of fluvastatin. In this case, the overall lipid-lowering effect is enhanced.
With simultaneous use with raloxifene, the absorption of raloxifene is reduced.
With simultaneous application with sulindac, the absorption of sulindac is reduced (even in the case of an interval between doses of 3 hours).
With simultaneous use with spironolactone, cases of hypochloremic alkalosis are described.
With simultaneous application with furosemide, absorption and diuretic effect of furosemide decreases.