The cardiovascular system: bradycardia, prolongation of the QT interval on the ECG.
Sense organs: very often there are visual impairments (fear of light, double vision, reduced vision, floating opacities of the vitreous, photophobia, the appearance of iridescent circles around the light source, a violation of the perception of the brightness of light).
Digestive system: very often - nausea and vomiting, diarrhea or constipation,gastroesophageal reflux and esophagitis, violation and pain when swallowing, pain in the esophagus, esophageal spasm, esophageal ulcer), abdominal pain, stomatitis, often - indigestion, rarely - liver failure.
Laboratory indicators: very often - an increase in the activity of hepatic transaminases, gamma-glutamyl transferase, impaired hepatic functional tests, impaired liver function, often - increased alkaline phosphatase activity.
Blood: often - neutropenia, leukopenia, lymphopenia, infrequently - thrombocytopenia.
Nervous system: very often - neuropathy, impaired gait, neurotoxicity, creeping sensation in the body, decreased muscle tone, optic neuritis, sensory change, sensory and motor disorder, peroneal nerve palsy, polyneuropathy, vertigo, imbalance, lightheadedness, headache, and insomnia.
Respiratory system: often - interstitial lung diseases, upper respiratory tract infections, dyspnea, cough.
Leather: very often - a rash.
Urinary system: often - multiple renal cysts.
Musculoskeletal system: very often - pain in the joints, in the back, in the chest, muscle weakness until atrophy.
Others: very often - swelling, fatigue, discomfort and chest pain, asthenia, fever, decreased appetite.