Xipamid (Xipamidum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Diuretics

Included in the formulation
АТХ:

C.03.B.A.10   Xipamid

Pharmacodynamics:

Diuretic medium strength. It disrupts the reabsorption of sodium, chlorine and equivalent amounts of water in the distal tubules of the nephron.In addition, increases the excretion of potassium, magnesium, bicarbonate ions, delays uric acid in the body.

Pharmacokinetics:

Maximum concentration is achieved After 1 hour. In blood, almost all (99%) is bound to proteins. Biotransformiruetsya in the liver with the formation of glucuronide. It is excreted mainly by the kidneys, a small part (in the form of glucuronide) is excreted with feces. Half-life in patients without impaired renal and hepatic function is 7 hours and varies insignificantly, even if urinary excretion is inhibited.

Indications:

Ocular syndrome of various genesis.

Arterial hypertension.

ICD-10

IX.I10-I15.I10   Essential [primary] hypertension

IX.I10-I15.I15   Secondary Hypertension

XVIII.R10-R19.R18   Ascites

XVIII.R50-R69.R60   Edema, not elsewhere classified

Contraindications:

Expressed violations of the liver and kidneys.

Disorders of electrolyte balance, not amenable to therapy.

Severe forms of gout and diabetes.

An untreated Addison's disease.

I trimester of pregnancy and breastfeeding.

Individual intolerance.

Carefully:No data.
Pregnancy and lactation:

Action category for the fetus by FDA - С. The drug is contraindicated in pregnancy and breastfeeding.

Dosing and Administration:

The dose is selected individually in each case. With swelling, the initial dose is 40 mg once in the morning, can be increased to 80 mg or reduced to 20 mg per day.

With arterial hypertension, the average dose of the drug is 20 mg per day once in the morning, sometimes - 10 mg.

Side effects:

Exchange processes: hypokalemia, hyponatremia, hypomagnesemia, hypochloraemic alkalosis, hyperuricemia.

Nervous system: headache, dizziness, drowsiness, muscle spasms, anxiety, agitation.

Digestive system: dry mouth, jaundice.

The cardiovascular system: Orthostatic hypotension, dyspeptic disorders, vasculitis.

Blood: increase clotting of blood, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia.

Urinary system: acute interstitial nephritis.

Leather: photosensitization.

Allergic reactions.

Overdose:

Characterized by the development of persistent diuresis, hypokalemia, arrhythmias, hyponatremia, arterial hypotension. Treatment is symptomatic.

Interaction:

Simultaneous use with non-steroidal anti-inflammatory drugs leads to a decrease in hypotensive and diuretic effect.

Against the background of other diuretics, nitrates, antihypertensive drugs, inhibitors ACE, barbiturates, phenothiazines, ethanol, tricyclic antidepressants increases the likelihood of excessive reduction blood pressure. Simultaneous use with hypoglycemic and antidotal agents, adrenaline and noradrenaline leads to a decrease in their effect.

The drug leads to strengthening cardio- and neurotoxicity of lithium preparations.

Simultaneous application with corticosteroids, cardiac glycosides, saluretic drugs, laxatives, carbenoxolone, amphotericin B, penicillin, salicylates leads to an increased risk of hypokalemia and / or hypomagnesemia. With simultaneous use with nondepolarizing muscle relaxants, neuromuscular blockade can be deepened.

Special instructions:

When the drug is administered, a level control potassium, sodium, urea, creatinine, uric acid, glucose, lipids in the blood. And also regular monitoring of blood pressure, heart rate and ECG. It is recommended to expand the drinking regime and food rich in potassium.

Instructions
Up