Included in the formulation
АТХ:C.01.B.G Other antiarrhythmic drugs I class
Pharmacodynamics:Alkaloid aconite white-tailed, antiarrhythmic drug I class. By blocking the "fast" sodium channels of the cardiomyocyte membranes causes a slowdown of intraventricular and atrioventricular conduction, shortens the functional and refractory periods of the atria, atrioventricular node, bundle of His and Purkinje fibers, does not affect the duration of the interval QT, conduction at the atrioventricular node in the anterograde direction, arterial pressure and heart rate, contractility of the myocardium. Do not depress the automatism of the sinus node. Does not have a negative inotropic and hypotensive effect.
Has mild anticholinergic, spasmolytic, coronary dilatation, sedative and local anesthetic action. The effect develops after oral administration after 40-60 minutes and reaches a maximum within 4-5 hours, lasts more than 8 hours.
Pharmacokinetics:Bioavailability of 40%. The drug undergoes primary passage through the liver. Penetrates through the blood-brain barrier.
The half-life is 1-1.2 hours.Elimination by the kidneys.
With cirrhosis of the liver half-life increases 3-10 times, with chronic renal failure - 2-3 times.
Indications:It is used for arrhythmias against a background of myocardial infarction, various forms of tachycardia, including paroxysmal forms of flutter and atrial fibrillation.
IX.I30-I52.I47.1 Nadzheludochkovaya tachycardia
IX.I30-I52.I47.2 Ventricular tachycardia
IX.I30-I52.I48 Atrial fibrillation and flutter
IX.I30-I52.I49.4 Other and unspecified depolarization
Contraindications:Atrioventricular block II and III degree, cardiogenic shock, arterial hypotension with systolic blood pressure below 90 mm. gt; st., postinfarction cardiosclerosis, children's age, individual intolerance, severe violations of the liver and kidneys.
Carefully:- Atrioventricular block of the 1st degree.
- Bradycardia.
- Closed-angle glaucoma.
- Hypertrophy of the prostate.
Pregnancy and lactation:Recommendations for FDA - Category C. The drug is contraindicated in pregnant and lactating women.
Dosing and Administration:Inside 12.5-25 mg 3-4 times a day for 30 minutes. before meals. It is recommended to drink warm water, grind the tablet before taking.
Intramuscularly: at 0.4 mg / kg every 6 hours.
Intravenously slowly: 0.3-0.4 mg / kg in 20 ml of 0.9% sodium chloride solution.
The highest daily dose: 150 mg.
The highest single dose: 300 mg.
Side effects:Central and peripheral nervous system: dizziness, headache, ataxia.
The cardiovascular system: sinus tachycardia, slowing of intraventricular conduction, arrhythmogenic action.
Sense organs: diplopia.
Allergic reactions.
Overdose:Symptoms: lowering of blood pressure, bradycardia, asystole.
Treatment: symptomatic.
Interaction:Strengthens the effect of nondepolarizing muscle relaxants.
The risk of side effects increases with simultaneous use of microsomal enzymes of the liver with inductors.
Special instructions:Before using the drug, electrolyte disturbances should be eliminated.
When treating patients, care should be taken when driving a motor vehicle and working with moving mechanisms.