Included in the formulation
АТХ:A.07.A.X Other intestinal antimicrobials
Pharmacodynamics:Polyene antifungal antibiotic.It has a high tropicity to the styrene structures of the fungal membrane, binding them, causing uncontrolled permeability, which leads to cell lysis.
Active with respect to Candida albicans and protozoa: leishmania, amoeba, Trichomonas.
Pharmacokinetics:It is not absorbed from the skin during external application, as well as in the gastrointestinal tract. After ingestion, it is excreted with feces.
Indications:It is used internally for the treatment of candidiasis of the gastrointestinal tract and with candidiasis. Locally - with candidiasis of genital organs. External - for the treatment of paronychias, lesions of the folds of the skin, interdigital erosion.
I.B35-B49.B37.0 Candidiasis stomatitis
I.B35-B49.B37.2 Candidiasis of skin and nails
I.B35-B49.B37.3 Candidiasis of the vulva and vagina (N77.1 *)
I.B35-B49.B37.4 Candidiasis of other urogenital localizations
I.B35-B49.B37.8 Candidiasis of other localizations
Contraindications:- Renal and hepatic insufficiency.
- Stomach ulcer and duodenal ulcer.
- Pancreatitis.
- Individual intolerance.
Carefully:Children under 2 years.
Pregnancy and lactation:Recommendations for FDA - category is not defined. During pregnancy and during lactation it is contraindicated.
Dosing and Administration:Inside for 500 thousand units 2-4 times a day for 10-12 days.
With candidiasis of female genital organs, 500,000 ED twice a day is intravaginal.
When candidiasis affects the oral mucosa, resorb the buccal tablet (500 thousand units) for 10-15 minutes 2-4 times a day. The course of treatment is 7-14 days.
The highest daily dose: 2 million units.
The highest single dose: 500 thousand units.
Side effects:Local irritating effect, headache, nausea, vomiting.
Allergic reactions.
Overdose:Cases of overdose are not described.
Interaction:Has an antagonistic effect when combined with antifungal agents - derivatives of azoles, exhibits synergism with respect to flucytosine.
Special instructions:With superficial mycoses, combined methods of application are used to improve efficacy: externally and internally.