Included in the formulation
АТХ:N.07.B.B Drugs used in alcohol dependence
Pharmacodynamics:Accelerates the excretion of ethanol and acetaldehyde from the body; activates the enzymes involved in the metabolism of ethanol. Restores the ratio of saturated and unsaturated free fatty acids in plasma, prevents primary structural degeneration of hepatocytes; inhibits the formation of fibronectin and collagen, inhibits the development of fibrosis and cirrhosis of the liver. Has anti-alcohol, hepatoprotective, detoxification effects. Reduces the severity of mental and physical symptoms of a hangover state, shortens the time of cupping of alcohol withdrawal syndrome.
Pharmacokinetics:Absorption is high. Bioavailability is 60-80%. Connection with plasma proteins - 50%. The half-life is 40-60 minutes. Biotransformation in the liver to active metabolites of pyridoxine and pyrrolidone carboxylate. It is excreted by the kidneys (45-50% within 24 hours) and with feces (35-50% for 96 hours).
Indications:Acute alcohol intoxication.
Alcohol withdrawal syndrome.
Chronic alcoholism.
Decreased desire for alcohol.
Toxic liver damage of alcoholic etiology.
Prevention of the formation of cirrhosis of alcoholic origin.
XXI.Z70-Z76.Z72.1 Alcohol consumption
V.F10-F19.F10.3 Mental and behavioral disorders caused by alcohol use - withdrawal symptoms
XI.K70-K77.K70.9 Alcoholic liver disease, unspecified
XIX.T51-T65.T51 Toxic effect of alcohol
Contraindications:Individual intolerance.
Pregnancy and breastfeeding.
Carefully:Assign with caution in Parkinson's disease, since metadoxine reduces the effectiveness of antiparkinsonian drugs.
Pregnancy and lactation:The category of FDA recommendations is not defined. The drug is contraindicated during pregnancy and breastfeeding.
Dosing and Administration:Alcoholic hepatopathy: inside, 500 mg 2-3 times a day or intramuscularly for 300 mg in dayki. The duration of treatment is at least 3 months.
Intramuscularly and intravenously drip in case of acute alcohol intoxication: 300-600 mg intramuscularly or 300-900 mg intravenously, depending on the degree of intoxication.
For aalcohol withdrawal syndrome: 900 mg in the form of intravenous infusion once a day for 3-7 days, depending on the patient's condition. Before intravenous the required amount is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose solution (glucose).
Side effects:Allergic reactions.
Bronchial spasm.
Interaction:Reduces the effectiveness of levodopa with simultaneous use.
Special instructions:No data.