Included in the formulation
АТХ:G.03.E.K Androgens and female sex hormones in combination with other drugs
G.03.E.K.01 Methyltestosterone
Pharmacodynamics:Fat-soluble drug, penetrates the membranes of cells of target organs, contacts the nucleus, activating the genetic apparatus of cells. It stimulates growth and development of the primary and secondary male sexual characteristics: growth and functional activity of prostate, seminal hillocks, scrotum, penis, provides hair growth of male type, roughness voice and thickening of the vocal cords, increasing muscle mass and reducing fat deposits. It detains sodium ions, nitrogen, carbonates and phosphates, reduces the excretion of calcium ions by the kidneys, contributing to their deposition in bone tissue. At pubertal age controls the growth of bones in length. Inhibits the synthesis of luteotropic and follicle-stimulating hormones of the pituitary gland. Promotes increased potency and libido in men, has antiestrogenic effect in the female body.
Pharmacokinetics:After ingestion rapidly and completely absorbed from the oral mucosa and gastrointestinal tract. The maximum concentration in the blood plasma is achieved after 2 hours.
Metabolism in the liver.
The elimination half-life is 3-4 hours. Elimination by the kidneys in the form of metabolites, about 10% - in unchanged form.
Indications:It is used in men with functional disorders in the genital area, menopause in men, sexual underdevelopment, in women with ovarian and breast cancer, dysfunctional uterine bleeding in the climacteric period.
II.C50.C50 Malignant neoplasm of breast
IV.E20-E35.E30.0 Delayed puberty
XIV.N80-N98.N95.1 Menopause and menopause in women
II.C51-C58.C56 Malignant neoplasm of ovary
XIV.N80-N98.N93.8 Other specified abnormal bleeding from the uterus and vagina
Contraindications:Renal and hepatic insufficiency, hypercalcemia, prostate cancer.
Individual intolerance.
Carefully:Arterial hypertension, heart failure, epilepsy, migraine.
Pregnancy and lactation:Recommendations for FDA - category X. The drug is contraindicated in pregnancy and lactation.
Dosing and Administration:Men: 10-40 mg once a day for 4-6 months. Women: 200 mg 1 time / day with a breast tumor.
The highest daily dose: 100 mg for men, 200 mg for women.
The highest single dose: 40 mg and 200 mg, respectively.
Side effects:Central and peripheral nervous system: dizziness, headache, depression, generalized paresthesia.
The cardiovascular system: edema.
Digestive system: nausea, cholestasis.
Dermatological reactions: acne.
Reproductive system: premature puberty in men, the phenomenon of masculinization in women.
Allergic reactions.
Overdose:Increased side effects.
Treatment is symptomatic.
Interaction:Strengthens the effects of insulin, indirect anticoagulants. Barbiturates, parathyroidine, cimetidine reduce the androgenic activity of the drug due to interaction with microsomal enzymes.
Special instructions:Monitoring of liver function, kidney function. Due to the pronounced anabolic effect in sports medicine, the drug is considered doping.