From the central nervous system and peripheral nervous system: increased fatigue, weakness, dizziness, headache, drowsiness, insomnia, nightmares, depression, anxiety, confusion, short-term memory loss, hallucinations, asthenic syndrome, muscle weakness, paresthesia in the extremities, tremor.
From the side of the organ of vision: blurred vision
, a decrease in the secretion of tear fluid, dryness and soreness of the eyes, conjunctivitis.
From the cardiovascular system: sinus bradycardia, palpitations, myocardial conduction disturbance, atrioventricular block (up to the development of complete transverse blockade and cardiac arrest), arrhythmias, weakening of myocardial contractility, development of chronic heart failure (swelling of the ankles, stop, dyspnea ), decreased blood pressure, orthostatic hypotension, manifestation of angiospasm (increased peripheral circulatory disturbance, lower extremities cooling, Raynaud's syndrome), chest pain.
On the part of the digestive system: dryness of the oral mucosa, nausea, vomiting, abdominal pain, diarrhea, constipation, impaired liver function (dark urine, icteric sclera or skin, cholestasis), changes in taste; change in the activity of enzymes, the level of bilirubin.
On the part of the respiratory system: nasal congestion, difficulty breathing, laryngo- and bronchospasm.
From the endocrine system: hyperglycemia (in patients with insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), hypothyroid status.
From the hemopoietic system: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia.
Allergic reactions: itching, rash, hives.
Dermatological reactions: increased sweating, skin hyperemia, exanthema, psoriasis-like skin reactions, exacerbation of psoriasis symptoms.
Others: back pain, arthralgia, weakening of libido, decreased potency, withdrawal syndrome (increased angina attacks, increased blood pressure).