Intravenously slowly (within 2-3 min), intramuscularly or subcutaneously.
When poisoning with opioid analgesics: initial dose - 0,4 mg, if necessary, again at intervals of 3-5 minutes until the onset of consciousness and recovery of spontaneous breathing, the maximum dose - 10 mg; children (initial dose) - 0,005-0,01 mg / kg.
To accelerate the withdrawal from surgical anesthesia: 0,1-0,2 mg (1.5-3 mkg / kg) every 2-3 minutes until adequate pulmonary ventilation and awakening occur; children - 0,001-0,002 mg / kg intravenously, in the absence of effect - repeatedly to 0.1 mg / kg every 2 minutes until the appearance of spontaneous breathing and recovery of consciousness. If intravenous injection is not possible, enter intramuscularly or subcutaneously with fractional doses; in newborns at the initial dose - 0,01 mg / kg.
When depression of respiration in newborns, caused by the introduction of narcotic analgesics during labor: 0,1 mg / kg intramuscularly, subcutaneously or intravenously, thereafter possibly a prophylactic dose administration 0,2 mg (0.06 mg / kg) intramuscularly.
For the purpose of diagnosing opioid addiction: 0,8 mg intravenously.