Sodium calcium edetate - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Included in the formulation

АТХ:

V.03.A.B Antidotes

Pharmacodynamics:

It is an antidote for poisoning by heavy metals and their compounds. The drug exchanges the calcium in the composition of the complex for ions of divalent and trivalent metals. As a result, low-toxic water-soluble compounds are formed, which are eliminated from the body. Calcium can be replaced by ions of zinc, cadmium, iron, cobalt, mercury, uranium, yttrium, cerium, manganese. Absorbed in organs of the digestive system in a small amount. When parenteral administration is fully associated with plasma proteins, does not penetrate the interior of the cell and is distributed extracellularly.

Pharmacokinetics:

The half-life is 20-60 minutes. It is excreted unchanged mainly by the kidneys (50% - within 1 hour, 95% - during the day).

Indications:

Acute and chronic poisoning by heavy and rare-earth metals and their compounds.

ICD-10

XIX.T51-T65.T56 Toxicity of metals

Contraindications:

- nephritis;

- nephrosis;

- Mr.the destruction of the liver and kidneys;

- pregnancy and the period of breastfeeding.

Carefully:No data.

Pregnancy and lactation:

The use is contraindicated in pregnancy and lactation.

Dosing and Administration:

With minimal signs of poisoning (the level of toxic substances is 20-70 μg / dL) is prescribed at 1000 mg / m² in a day intramuscularly or intravenously. Intravenously drip: in an isotonic solution of sodium chloride or in a 5% solution of glucose, a single dose of 2 g (20 ml of 10% solution), a daily dose of 4 g. The course of treatment: daily for 3-4 days followed by a break for 3-4 days - 1 month.

Side effects:

Urinary system: acute necrosis of proximal tubules, damage of distal tubules and renal glomerulus, glucosuria, proteinuria, microhematuria.

The cardiovascular system: hypotension, heart rhythm disturbances.

Nervous system: tremor, headache, ringing in the ears, encephalopathy (in children).

Blood: bone marrow depression, anemia.

Digestive system: nausea, vomiting, anorexia, thirst, sneezing, nasal congestion, lacrimation, lowering of zinc in the blood.

Others: fever, chills, myalgia, arthralgia, weakness, pain in place intramuscular introduction.

Overdose:When an overdose is observed increased side effects, cerebral edema, renal tubular necrosis.For treatment, mannitol is prescribed (to reduce brain edema), forced diuresis, symptomatic therapy to maintain vital functions.

Interaction:

No data.

Special instructions:

During treatment, the activity of alkaline phosphatase is significantly reduced.

To reduce the likelihood of side effects, it is recommended that an adequate diuresis be provided before therapy begins, and then maintained. It is necessary to warn the patient about the need to inform the doctor in case of delay of urination for more than 12 hours.

Instructions

Sodium calcium edetate (Natrii-calcii edetas)