Included in the formulation
АТХ:A.11.H.A Other vitamins
A.11.H.A.01 Nicotinamide
Pharmacodynamics:Is a substrate for the synthesis of nicotinadenine nucleotide (NAD-codeegirdase I) and nicotinadenine nucleotide phosphate (NADP-codeogirdase II), which accept and transfer protons in oxidation-reduction reactions, providing all types of exchange, including energy. It improves nitrogen and carbohydrate metabolism, provides tissue respiration.
With a lack of nicotinic acid, a pellagra develops.
Nicotinamide does not cause vasodilator action, after its application, there is no rush of blood to the skin of the face and head.
Pharmacokinetics:After ingestion after meals, up to 60-70% is absorbed in the gastrointestinal tract. It is distributed in all tissues of the body. It penetrates the placental barrier and enters the breast milk.
Therapeutic effect develops after the reception. Metabolism in the liver before the formation of nicotinamide-N-methylnicotinamide.
The half-life is 45 minutes. Elimination by the kidneys.
Indications:It is used for the treatment of pellagra, with hepatitis, gastritis with low acidity, atherosclerosis, infectious diseases. Used for the healing of flaccid wounds and ulcers, including diabetes mellitus.
IV.E10-E14.E14 Diabetes mellitus, unspecified
XI.K20-K31.K26 Duodenal ulcer
XI.K20-K31.K25 Stomach ulcer
XI.K50-K52.K52.8 Other specified non-infectious gastroenteritis and colitis
XIX.T08-T14.T14.1 Open wound of unspecified area of the body
Contraindications:Uncontrolled arterial hypertension, angina pectoris, glaucoma, individual intolerance.
Pregnancy and lactation:Recommendations for FDA - Category C when using doses higher than recommended.
Dosing and Administration:Use in children
Inside for 5-10 mg 1-2 times / day.
Adults
Inside for 50-100 mg 3-4 times / day. Parenteral: 1-2 ml of 1, 2.5 and 5% solution 1-2 times / day.
The highest daily dose: 0.5 g.
The highest single dose: 100 mg.
Side effects:Allergic reactions. With prolonged use, the development of fatty liver dystrophy is possible.
Interaction:At simultaneous application with the vitamin preparations containing a nicotinic acid the strengthening of adverse effects is noted.
When you drink alcohol during treatment, it may cause itching and rashes.
Special instructions:Possible use for the treatment of benzodiazepine dependence.
With long-term treatment, methionine is recommended for the prevention of fatty liver dystrophy.