Included in the formulation
АТХ:P.01.A.B Nitroimidazole derivatives
P.01.A.B.06 Nimorazole
Pharmacodynamics:The nitro-5-imidazole derivative has an antibacterial and antiprotozoal effect. It recovers 5-nitro group due to transport proteins of anaerobic bacteria and protozoan microorganisms. The reduced 5-nitro group of nimorazole inhibits the synthesis of nucleic acids from the DNA of microorganism cells, which leads to their death.
It is active against Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, and also against Lamblia intestinalis.
Pharmacokinetics:After oral administration, it is completely absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 3 hours. The connection with plasma proteins is 20%.
Therapeutic effect develops within 1-3 hours after the reception. Metabolism in the liver with the formation of active metabolites.
The elimination half-life is 8 hours. Elimination by the kidneys.
Indications:It is used for the treatment of trichomonas infection, giardiasis, amoebic dysentery.
I.A50-A64.A59 Trichomoniasis
Contraindications:Organic damage to the central nervous system (epilepsy), hepatic insufficiency, individual intolerance.
Carefully:Disturbances of microcirculation, diabetes mellitus.
Pregnancy and lactation:Recommendations for FDA - Category B. Contraindicated in I trimester of pregnancy and lactation.
Dosing and Administration:Inside after a meal: over 5 years of 10 mg / kg 2 times / day for a week.
Adults: inside after eating 1 gram every 12 hours for a week.
The highest daily dose: 2 g.
The highest single dose: 1 g.
Side effects:Central nervous system: headache, dizziness.
Hemopoietic system: leukocytosis or leukopenia.
Digestive system: nausea, a sense of metallic taste in the mouth, a decrease in appetite, constipation, or diarrhea.
Allergic reactions.
Overdose:Symtomas: vomiting, diarrhea, ataxia, paresthesia, convulsions.
Treatment: symptomatic. Effective hemodialysis.
Interaction:With the simultaneous use of alcohol, disulfiramoid reactions develop: skin hyperemia, vomiting, cramping pains in the lower abdomen.
Strengthens the effect of indirect coagulants.
It is not compatible with nondepolarizing muscle relaxants (faithful bromide).
With simultaneous use, accelerate elimination and reduce the concentration of nimorazole in blood plasma preparations that stimulate enzymes of microsomal oxidation in the liver (feniotion, phenobarbital).
Enhances the toxic effects of lithium preparations.
With simultaneous use with cimetidine, the concentration of nimorazole in the blood serum increases, which leads to an increase in side effects.
Special instructions:In the treatment of trichomonas infection requires simultaneous treatment of sexual partners and abstinence from sexual activity for the period of taking the drug.