Parnaparin sodium (Natrii parnaparinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Anticoagulants

Included in the formulation
  • Fluxum®
    solution PC 
    Alfa Wassermann SpA     Italy
    • АТХ:

    B.01.A.B   Heparin and its derivatives

    Pharmacodynamics:

    Enhances blockade of antithrombin-activated III factors of blood coagulation, inactivates factor Xa, inhibits coagulation and formation of a blood clot. Accelerates the formation of complexes of thrombin with antithrombin III, slowing the transformation of fibrinogen into fibrin and the organization of a thrombus. Reduces the aggregation of platelets.

    Pharmacokinetics:

    After subcutaneous administration, the maximum concentration in the blood plasma is reached after 2-3 hours.

    The therapeutic effect persists for 20 hours after the injection. Metabolism in the liver.

    The half-life is 6 hours. Elimination by the kidneys.

    Indications:

    It is used for the treatment of thrombophlebitis, varicophlebitis, chronic venous insufficiency, deep vein thrombosis, is used to prevent thrombosis during surgical and orthopedic operations.

    ICD-10

    IX.I80-I89.I80   Phlebitis and thrombophlebitis

    IX.I80-I89.I82   Embolism and thrombosis of other veins

    IX.I80-I89.I83   Varicose veins

    IX.I80-I89.I85   Varicose veins of the esophagus

    IX.I80-I89.I87.0   Postphlebitic syndrome

    IX.I80-I89.I87.2   Venous insufficiency (chronic) (peripheral)

    Contraindications:
    • Conditions and diseases, accompanied by a decrease in blood clotting: thrombocytopenia, a deficiency of coagulation factors, hemorrhagic diathesis.
    • Ulcers of the stomach and duodenum.
    • Acute bacterial endocarditis.
    • Hemorrhagic stroke.
    • Ulcerative colitis.
    • Individual intolerance.
    Carefully:

    Renal and hepatic insufficiency.

    Pregnancy and lactation:

    Recommendations by FDA - Category C. It is used in pregnancy in cases where the potential benefit of the drug exceeds the possible risk to the fetus. Contraindicated during lactation.

    Dosing and Administration:

    Subcutaneously for 0.4-0.6 ml every 12 hours for 10 days.

    The highest daily dose: 1.2 ml (12800 IU aha).

    The highest single dose: 0.6 ml (6400 IU aha).

    Side effects:

    Blood coagulation system: thrombocytopenia.

    Local reactions: necrosis or bruising at the injection site.

    Allergic reactions.

    Overdose:

    Symptoms: bleeding.

    Treatment: symptomatic.

    Interaction:

    The risk of bleeding increases with simultaneous use with salicylates, indirect coagulants, glucocorticoids, nonsteroidal anti-inflammatory drugs, antiaggregants.

    Special instructions:

    Monitoring the amount of peripheral blood platelets.

    Instructions
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