Included in the formulation
АТХ:A.03.A.X.04 Pihaveria
Pharmacodynamics:Selective blockade of calcium channels of smooth muscle cells of intestines and bile ducts, weak m-cholinoblocking action. The drug has an antispasmodic effect.
Pharmacokinetics:Absorption is less than 10% (quaternary ammonium base). The connection with plasma proteins is 97%. Half-life is 1.5 hours. Biotransformation in the liver. Elimination mainly with feces, a small part of the kidneys.
Indications:Symptomatic elimination of pain and violations of the motility of the gastrointestinal tract with intestinal spasms, irritable bowel syndrome, dyskinesia of bile ducts. Preparation for X-ray examination of the gastrointestinal tract with contrasting.
XI.K55-K63.K58 Irritable Bowel Syndrome
XI.K94.K94 * Diagnosis of diseases of the digestive tract
XVIII.R10-R19.R10.4 Other and unspecified abdominal pain
Contraindications:Paralytic obstruction of the intestine, atony of the intestine, toxic megacolon, severe ulcerative colitis, individual intolerance.
Carefully:Pregnancy, breast-feeding, children's age.
Pregnancy and lactation:When pregnancy and lactation are prescribed only in cases,when the intended use for the mother exceeds the potential risk to the fetus or child.
Dosing and Administration:Inside to 50 mg 3 times a day or 100 mg 2 times a day (during meals). If necessary, the dose may be increased to 300 mg per day.
When preparing for radiographic examination - 200 mg per day daily for 3 days preceding the procedure.
Side effects:Digestive system: dyspepsia, constipation, nausea.Allergic reactions.
Overdose:Cases of overdose are not described. Treatment is symptomatic.
Interaction:Simultaneous administration of anticholinergics can increase the cramping of spasms.
Special instructions:In connection with the risk of damage to the mucous membrane of the esophagus, you must carefully follow the recommendations for use. Patients with esophagitis and / or hernia of the esophagus should pay special attention to the correct use of the drug.