Pipotiazine (Pipothiazinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Neuroleptics

Included in the formulation
АТХ:

N.05.A.C.04   Pipotiazine

Pharmacodynamics:Competitive blockade of postsynaptic dopamine D2receptors in the mesolimbic structures of the brain. Has a strong extrapyramidal effect, weak - antiemetic, anticholinergic, sedative, hypotensive. Particularly effective in the paranoid form of schizophrenia, chronic psychoses with hallucinations, chronic delirium, as well as manic attacks, excitation conditions.
Pharmacokinetics:The connection with plasma proteins is 90%. Biotransformation in the liver. The half-life is 30 ± 7 hours. Elimination by the kidneys (less than 1%) and with feces. The effect of presystemic elimination is characteristic.
Indications:Chronic psychosis.

Schizophrenia (paranoid or deficit form), hebephrenia, hallucinatory and affective-delusional states (chronic forms).

Acute psychosis and acute attacks of chronic psychosis, bouts of delirium of various etiologies, psychomotor agitation, manic attacks.

In the treatment of acute psychotic conditions.

ICD-10

V.F20-F29.F20   Schizophrenia

V.F20-F29.F20.0   Paranoid schizophrenia

V.F20-F29.F20.1   Gebefrenic schizophrenia

V.F20-F29.F22.0   Delusional Disorder

V.F20-F29.F29   Inorganic psychosis, unspecified

V.F30-F39.F39   Mood disturbance [affective], unspecified

XVIII.R40-R46.R44.3   Other hallucinations

XVIII.R40-R46.R45.1   Anxiety and Excitement

Contraindications:Hypersensitivity.

Toxic agranulocytosis (in the anamnesis).

Closed-angle glaucoma.

Porphyria.

Hyperplasia of the prostate.

Pregnancy, breast-feeding.

Carefully:No data.
Pregnancy and lactation:The drug is contraindicated during pregnancy and breastfeeding.
Dosing and Administration:Chronic and acute psychosis, schizophrenia: inside once a day (usually in the morning). The initial dose is up to 0.01 g. The average therapeutic dose is 0.02-0.03 g. If necessary, the dose is increased to 0.06 g per day.

Solution for injection and depot form is used after taking the drug inside strictly intramuscularly once in 4 weeks; adults - to 0.025-0.2 g.

For elderly patients with epilepsy and alcoholism, the initial dose is 0.025 g.

Side effects:Nervous system and sensory organs: depression, early dyskinesia (spasmodic torticollis, oculomotor crisis, trism), extrapyramidal disorders, tardive dyskinesia, excessive sedation.

The cardiovascular system: orthostatic hypotension, lowering blood pressure.

Blood: agranulocytosis.

Others: Cholestatic jaundice, amenorrhea, galactorrhea, gynecomastia, hyperprolactinaemia, weight gain, anticholinergic effects (dry mouth, constipation, accommodation pause, urinary retention), impotence, frigidity, allergic reactions, photosensitivity.

Overdose:Not described.
Interaction:Alcohol and other drugs that cause depression of the central nervous system - increased oppression.

Levodopa - weakening of the effect.

Metrizamide - a decrease in its effect (reduction of the convulsive threshold).

Lithium preparations - a decrease in the absorption of phenothiazines in the gastrointestinal tract by 40%, an increase in the rate of lithium excretion by the kidneys, an increase in the severity of extrapyramidal disorders.

Means that elongate the QT interval (astemizole, cisapride, probucol, disopyramide, erythromycin, procainamide) - risk of arrhythmia.

Means that cause hypotension - severe hypotension, syncope.

Means that cause extrapyramidal reactions - an increase in the incidence and severity of extrapyramidal disorders.

Means for the treatment of hyperthyroidism - the risk of agranulocytosis.

Tricyclic antidepressants, maprotiline, MAO inhibitors - prolonged duration and increased sedative and anticholinergic effects.

Epinephrine - a paradoxical reduction in blood pressure and tachycardia.

Special instructions:Intramuscular administration is allowed only after verifying the tolerability of pipothiazine when ingested. Do not administer intravenously.
Instructions
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