Included in the formulation
АТХ:N.01.A.X Other drugs for general anesthesia
N.01.A.X.04 Propanidide
Pharmacodynamics: Means for non-anional anesthesia.
Analgesia during anesthesia with propanidide is poorly expressed. Propanidide causes a rapid and significant reduction in cerebral blood flow with recovery to about 10 minutes after drug administration.
Poslenaruskoznogo oppression of the central nervous system is not noted. Before the onset of anesthesia, there may be hyperventilation with a short apnea, but in the stage of surgical anesthesia, breathing normalizes. Possible a small tachycardia, some hypotension. At the beginning of the drug in a number of patients muscular twitchings are noted. Propanidide has a moderate irritant effect, which is usually manifested by flushing and pain sensations along the veins. Blood clots are possible. Allergic reactions are possible. Use propanidide for introductory anesthesia and for short-term operations. It is especially convenient for outpatient practice, since in 20-30 minutes the psychomotor functions are completely restored.
Pharmacokinetics:The effect after intravenous administration develops in 20-40 s without the stage of excitation; deep anesthesia lasts for 4-10 minutes (propanidide rapidly hydrolyzed by blood cholinesterase),while retaining corneal and pupillary reflexes; consciousness is restored 2-3 minutes after the end of the surgical stage of anesthesia. Promotes the release of histamine from mast cells.
In the liver it is destroyed. Biotransformation products are excreted by the kidneys.
Indications:Anesthetic for short-term dental(surgery of dislocations, reposition of bone fragments, removal of sutures, catheterization), interventions, painful instrumental diagnostic or therapeutic procedures (endoscopy, bronchography, biopsy, etc.), anesthesia (for operations requiring prolonged anesthesia for potentiation actions of other anesthesia), anesthesia of childbirth (the period of fetal expulsion).
XVIII.R50-R69.R52.0 Acute pain
XX.Y83-Y84.Y83.8 Other Surgery
Contraindications:Hypersensitivityshock, hemolytic jaundice, severe impairment of liver and kidney function, circulatory insufficiency, incl. coronary, or cardiac activity, hypertension, acute alcohol intoxication, propensity to convulsions or bronchospasm, children (up to 4 years) and elderly (after 60 years) age.
Pregnancy and lactation:No data.
Dosing and Administration:Intravenously slowly, using a needle with a wide lumen (due to the relatively high viscosity of the solution). The dose is determined individually, taking into account the age, body weight, severity of the condition, the nature of the surgical intervention and the general condition of the patient. Adults to ensure a 5-minute anesthesia - 500 mg. The average dose is 5-10 mg / kg (5% solution). Weakened patients and the elderly dose is 2-3 mg / kg (2.5% solution). Children under 4 years old - 100-150 mg, 4-6 years - 150-200 mg, 6-10 years - 200-300 mg, 10-16 years - 300-500 mg, over 16 years - depending on the development and general state, at the rate of 5-7-10 mg / kg body weight. To prolong the action (with the appearance of a blinking reflex), you can re-enter in a dose of 2/3 or 3/4 of the original (not more than 1.5-2 g).
Side effects:Hyperventilation with short apnea, bronchospasm, tachycardia, hypertension, nausea, vomiting, hiccough, muscle twitching, sweating; thrombophlebitis, hyperemia and tenderness along the vein at the site of administration.
Overdose:Symptoms: the agonal stage of anesthesia, severe suppression of the respiratory and vasomotor centers, a decrease in the volume and frequency of breathing, asphyxia, heart failure, a drop in blood pressure, and dilatation of the pupils.
Treatment: elimination activities (with mandatory termination of the introduction), maintenance of vital functions.
Special instructions:To prevent thrombophlebitis, the needle left for subsequent injections in the vein should be washed with saline or novocaine. With caution combine with atropine and antihypertensives.
In connection with the possibility of developing severe anaphylactoid reactions due to the ethoxylated castor oil contained in the finished dosage form (as a filler), the use of propanidide is limited.